Cargando…

Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance

The integration of hydroxyapatite (HA) with broad-spectrum bactericidal nano-silver within biopolymer-based bone scaffolds not only promotes new bone growth, but also effectively prevents bacterial infections. However, there are problems such as a poor interface compatibility and easy agglomeration....

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Jingxi, Cheng, Chen, Yang, Youwen, Zan, Jun, Shuai, Cijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647501/
https://www.ncbi.nlm.nih.gov/pubmed/37947674
http://dx.doi.org/10.3390/nano13212828
_version_ 1785135121877172224
author Huang, Jingxi
Cheng, Chen
Yang, Youwen
Zan, Jun
Shuai, Cijun
author_facet Huang, Jingxi
Cheng, Chen
Yang, Youwen
Zan, Jun
Shuai, Cijun
author_sort Huang, Jingxi
collection PubMed
description The integration of hydroxyapatite (HA) with broad-spectrum bactericidal nano-silver within biopolymer-based bone scaffolds not only promotes new bone growth, but also effectively prevents bacterial infections. However, there are problems such as a poor interface compatibility and easy agglomeration. In this project, zeolitic imidazolate frameworks (ZIF-8) were grown in situ on nano-HA to construct a core–shell structure, and silver was loaded into the ZIF-8 shell through ion exchange. Finally, the core–shell structure (HA@Ag) was composited with polylactic acid (PLLA) to prepare bone scaffolds. In this case, the metal zinc ions of ZIF-8 could form ionic bonds with the phosphate groups of HA by replacing calcium ions, and the imidazole ligands of ZIF-8 could form hydrogen bonds with the carboxyl groups of the PLLA, thus enhancing the interface compatibility between the biopolymers and ceramics. Additionally, the frame structure of MOFs enabled controlling the release of silver ions to achieve a long-term antibacterial performance. The test results showed that the HA@Ag nanoparticles endowed the scaffold with good antibacterial and osteogenic activity. Significantly, the HA@Ag naoaprticle exhibited a good interfacial compatibility with the PLLA matrix and could be relatively evenly dispersed within the matrix. Moreover, the HA@ZIF-8 also effectively enhanced the mechanical strength and degradation rate of the PLLA scaffold.
format Online
Article
Text
id pubmed-10647501
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106475012023-10-25 Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance Huang, Jingxi Cheng, Chen Yang, Youwen Zan, Jun Shuai, Cijun Nanomaterials (Basel) Article The integration of hydroxyapatite (HA) with broad-spectrum bactericidal nano-silver within biopolymer-based bone scaffolds not only promotes new bone growth, but also effectively prevents bacterial infections. However, there are problems such as a poor interface compatibility and easy agglomeration. In this project, zeolitic imidazolate frameworks (ZIF-8) were grown in situ on nano-HA to construct a core–shell structure, and silver was loaded into the ZIF-8 shell through ion exchange. Finally, the core–shell structure (HA@Ag) was composited with polylactic acid (PLLA) to prepare bone scaffolds. In this case, the metal zinc ions of ZIF-8 could form ionic bonds with the phosphate groups of HA by replacing calcium ions, and the imidazole ligands of ZIF-8 could form hydrogen bonds with the carboxyl groups of the PLLA, thus enhancing the interface compatibility between the biopolymers and ceramics. Additionally, the frame structure of MOFs enabled controlling the release of silver ions to achieve a long-term antibacterial performance. The test results showed that the HA@Ag nanoparticles endowed the scaffold with good antibacterial and osteogenic activity. Significantly, the HA@Ag naoaprticle exhibited a good interfacial compatibility with the PLLA matrix and could be relatively evenly dispersed within the matrix. Moreover, the HA@ZIF-8 also effectively enhanced the mechanical strength and degradation rate of the PLLA scaffold. MDPI 2023-10-25 /pmc/articles/PMC10647501/ /pubmed/37947674 http://dx.doi.org/10.3390/nano13212828 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Jingxi
Cheng, Chen
Yang, Youwen
Zan, Jun
Shuai, Cijun
Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance
title Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance
title_full Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance
title_fullStr Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance
title_full_unstemmed Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance
title_short Zeolitic Imidazolate Frameworks Serve as an Interface Layer for Designing Bifunctional Bone Scaffolds with Antibacterial and Osteogenic Performance
title_sort zeolitic imidazolate frameworks serve as an interface layer for designing bifunctional bone scaffolds with antibacterial and osteogenic performance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647501/
https://www.ncbi.nlm.nih.gov/pubmed/37947674
http://dx.doi.org/10.3390/nano13212828
work_keys_str_mv AT huangjingxi zeoliticimidazolateframeworksserveasaninterfacelayerfordesigningbifunctionalbonescaffoldswithantibacterialandosteogenicperformance
AT chengchen zeoliticimidazolateframeworksserveasaninterfacelayerfordesigningbifunctionalbonescaffoldswithantibacterialandosteogenicperformance
AT yangyouwen zeoliticimidazolateframeworksserveasaninterfacelayerfordesigningbifunctionalbonescaffoldswithantibacterialandosteogenicperformance
AT zanjun zeoliticimidazolateframeworksserveasaninterfacelayerfordesigningbifunctionalbonescaffoldswithantibacterialandosteogenicperformance
AT shuaicijun zeoliticimidazolateframeworksserveasaninterfacelayerfordesigningbifunctionalbonescaffoldswithantibacterialandosteogenicperformance