Cargando…

Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures

A special generative manufacturing (AM) process was developed for the partial integration of active ingredients into open-porous matrix structures. A mixture of a silver-containing solution as an antibacterial material with an alginate hydrogel as a carrier system was produced as the active ingredie...

Descripción completa

Detalles Bibliográficos
Autores principales: Burger, Lena, Conzelmann, Achim, Ulrich, Sven, Mozaffari-Jovein, Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647568/
https://www.ncbi.nlm.nih.gov/pubmed/37959583
http://dx.doi.org/10.3390/ma16216985
_version_ 1785135137462157312
author Burger, Lena
Conzelmann, Achim
Ulrich, Sven
Mozaffari-Jovein, Hadi
author_facet Burger, Lena
Conzelmann, Achim
Ulrich, Sven
Mozaffari-Jovein, Hadi
author_sort Burger, Lena
collection PubMed
description A special generative manufacturing (AM) process was developed for the partial integration of active ingredients into open-porous matrix structures. A mixture of a silver-containing solution as an antibacterial material with an alginate hydrogel as a carrier system was produced as the active ingredient. The AM process developed was used to introduce the active ingredient solution into an open-porous niobium containing a β-titanium matrix structure, thus creating a reproducible active ingredient delivery system. The matrix structure had already been produced in a separate AM process by means of selective laser melting (SLM). The main advantage of this process is the ability to control porosity with high precision. To determine optimal surface conditions for the integration of active ingredients into the matrix structure, different surface conditions of the titanium substrate were tested for their impact on wetting behaviour of a silver-containing hydrogel solution. The solution-substrate contact angle was measured and evaluated to determine the most favourable surface condition. To develop the generative manufacturing process, an FDM printer underwent modifications that permitted partial application of the drug solution to the structure in accordance with the bioprinting principle. The modified process enabled flexible control and programming of both the position and volume of the applied drug. Furthermore, the process was able to fill up to 95% of the titanium matrix body pore volume used. The customised application of drug carriers onto implants as a drug delivery system can be achieved via the developed process, providing an alternative to established methods like dip coating that lack this capability.
format Online
Article
Text
id pubmed-10647568
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106475682023-10-31 Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures Burger, Lena Conzelmann, Achim Ulrich, Sven Mozaffari-Jovein, Hadi Materials (Basel) Article A special generative manufacturing (AM) process was developed for the partial integration of active ingredients into open-porous matrix structures. A mixture of a silver-containing solution as an antibacterial material with an alginate hydrogel as a carrier system was produced as the active ingredient. The AM process developed was used to introduce the active ingredient solution into an open-porous niobium containing a β-titanium matrix structure, thus creating a reproducible active ingredient delivery system. The matrix structure had already been produced in a separate AM process by means of selective laser melting (SLM). The main advantage of this process is the ability to control porosity with high precision. To determine optimal surface conditions for the integration of active ingredients into the matrix structure, different surface conditions of the titanium substrate were tested for their impact on wetting behaviour of a silver-containing hydrogel solution. The solution-substrate contact angle was measured and evaluated to determine the most favourable surface condition. To develop the generative manufacturing process, an FDM printer underwent modifications that permitted partial application of the drug solution to the structure in accordance with the bioprinting principle. The modified process enabled flexible control and programming of both the position and volume of the applied drug. Furthermore, the process was able to fill up to 95% of the titanium matrix body pore volume used. The customised application of drug carriers onto implants as a drug delivery system can be achieved via the developed process, providing an alternative to established methods like dip coating that lack this capability. MDPI 2023-10-31 /pmc/articles/PMC10647568/ /pubmed/37959583 http://dx.doi.org/10.3390/ma16216985 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Burger, Lena
Conzelmann, Achim
Ulrich, Sven
Mozaffari-Jovein, Hadi
Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures
title Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures
title_full Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures
title_fullStr Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures
title_full_unstemmed Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures
title_short Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures
title_sort process development of a generative method for partial and controlled integration of active substances into open-porous matrix structures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647568/
https://www.ncbi.nlm.nih.gov/pubmed/37959583
http://dx.doi.org/10.3390/ma16216985
work_keys_str_mv AT burgerlena processdevelopmentofagenerativemethodforpartialandcontrolledintegrationofactivesubstancesintoopenporousmatrixstructures
AT conzelmannachim processdevelopmentofagenerativemethodforpartialandcontrolledintegrationofactivesubstancesintoopenporousmatrixstructures
AT ulrichsven processdevelopmentofagenerativemethodforpartialandcontrolledintegrationofactivesubstancesintoopenporousmatrixstructures
AT mozaffarijoveinhadi processdevelopmentofagenerativemethodforpartialandcontrolledintegrationofactivesubstancesintoopenporousmatrixstructures