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Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures
A special generative manufacturing (AM) process was developed for the partial integration of active ingredients into open-porous matrix structures. A mixture of a silver-containing solution as an antibacterial material with an alginate hydrogel as a carrier system was produced as the active ingredie...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647568/ https://www.ncbi.nlm.nih.gov/pubmed/37959583 http://dx.doi.org/10.3390/ma16216985 |
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author | Burger, Lena Conzelmann, Achim Ulrich, Sven Mozaffari-Jovein, Hadi |
author_facet | Burger, Lena Conzelmann, Achim Ulrich, Sven Mozaffari-Jovein, Hadi |
author_sort | Burger, Lena |
collection | PubMed |
description | A special generative manufacturing (AM) process was developed for the partial integration of active ingredients into open-porous matrix structures. A mixture of a silver-containing solution as an antibacterial material with an alginate hydrogel as a carrier system was produced as the active ingredient. The AM process developed was used to introduce the active ingredient solution into an open-porous niobium containing a β-titanium matrix structure, thus creating a reproducible active ingredient delivery system. The matrix structure had already been produced in a separate AM process by means of selective laser melting (SLM). The main advantage of this process is the ability to control porosity with high precision. To determine optimal surface conditions for the integration of active ingredients into the matrix structure, different surface conditions of the titanium substrate were tested for their impact on wetting behaviour of a silver-containing hydrogel solution. The solution-substrate contact angle was measured and evaluated to determine the most favourable surface condition. To develop the generative manufacturing process, an FDM printer underwent modifications that permitted partial application of the drug solution to the structure in accordance with the bioprinting principle. The modified process enabled flexible control and programming of both the position and volume of the applied drug. Furthermore, the process was able to fill up to 95% of the titanium matrix body pore volume used. The customised application of drug carriers onto implants as a drug delivery system can be achieved via the developed process, providing an alternative to established methods like dip coating that lack this capability. |
format | Online Article Text |
id | pubmed-10647568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106475682023-10-31 Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures Burger, Lena Conzelmann, Achim Ulrich, Sven Mozaffari-Jovein, Hadi Materials (Basel) Article A special generative manufacturing (AM) process was developed for the partial integration of active ingredients into open-porous matrix structures. A mixture of a silver-containing solution as an antibacterial material with an alginate hydrogel as a carrier system was produced as the active ingredient. The AM process developed was used to introduce the active ingredient solution into an open-porous niobium containing a β-titanium matrix structure, thus creating a reproducible active ingredient delivery system. The matrix structure had already been produced in a separate AM process by means of selective laser melting (SLM). The main advantage of this process is the ability to control porosity with high precision. To determine optimal surface conditions for the integration of active ingredients into the matrix structure, different surface conditions of the titanium substrate were tested for their impact on wetting behaviour of a silver-containing hydrogel solution. The solution-substrate contact angle was measured and evaluated to determine the most favourable surface condition. To develop the generative manufacturing process, an FDM printer underwent modifications that permitted partial application of the drug solution to the structure in accordance with the bioprinting principle. The modified process enabled flexible control and programming of both the position and volume of the applied drug. Furthermore, the process was able to fill up to 95% of the titanium matrix body pore volume used. The customised application of drug carriers onto implants as a drug delivery system can be achieved via the developed process, providing an alternative to established methods like dip coating that lack this capability. MDPI 2023-10-31 /pmc/articles/PMC10647568/ /pubmed/37959583 http://dx.doi.org/10.3390/ma16216985 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Burger, Lena Conzelmann, Achim Ulrich, Sven Mozaffari-Jovein, Hadi Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures |
title | Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures |
title_full | Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures |
title_fullStr | Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures |
title_full_unstemmed | Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures |
title_short | Process Development of a Generative Method for Partial and Controlled Integration of Active Substances into Open-Porous Matrix Structures |
title_sort | process development of a generative method for partial and controlled integration of active substances into open-porous matrix structures |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647568/ https://www.ncbi.nlm.nih.gov/pubmed/37959583 http://dx.doi.org/10.3390/ma16216985 |
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