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Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer

In this study, we aimed to assess the prevalence of interstitial lung abnormalities (ILAs) and investigate the rates and risk factors associated with radiologic ILA progression among patients with lung cancer following surgical resection. Patients who underwent surgical resection for lung cancer at...

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Autores principales: Shin, Yoon Joo, Yi, Jeong Geun, Kim, Mi Young, Son, Donghee, Ahn, Su Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647667/
https://www.ncbi.nlm.nih.gov/pubmed/37959324
http://dx.doi.org/10.3390/jcm12216858
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author Shin, Yoon Joo
Yi, Jeong Geun
Kim, Mi Young
Son, Donghee
Ahn, Su Yeon
author_facet Shin, Yoon Joo
Yi, Jeong Geun
Kim, Mi Young
Son, Donghee
Ahn, Su Yeon
author_sort Shin, Yoon Joo
collection PubMed
description In this study, we aimed to assess the prevalence of interstitial lung abnormalities (ILAs) and investigate the rates and risk factors associated with radiologic ILA progression among patients with lung cancer following surgical resection. Patients who underwent surgical resection for lung cancer at our institution from January 2015 to December 2020 were retrospectively evaluated and grouped according to their ILA status as having no ILAs, equivocal ILAs, or ILAs. Progression was determined by simultaneously reviewing the baseline and corresponding follow-up computed tomography (CT) scans. Among 346 patients (median age: 67 (interquartile range: 60–74) years, 204 (59.0%) men), 22 (6.4%) had equivocal ILAs, and 33 (9.5%) had ILAs detected upon baseline CT. Notably, six patients (6/291; 2.1%) without ILAs upon baseline CT later developed ILAs, and 50% (11/22) of those with equivocal ILAs exhibited progression. Furthermore, 75.8% (25/33) of patients with ILAs upon baseline CT exhibited ILA progression (76.9% and 71.4% with fibrotic and non-fibrotic ILAs, respectively). Multivariate analysis revealed that ILA status was a significant risk factor for ILA progression. ILAs and equivocal ILAs were associated with radiologic ILA progression after surgical resection in patients with lung cancer. Hence, early ILA detection can significantly affect clinical outcomes.
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spelling pubmed-106476672023-10-30 Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer Shin, Yoon Joo Yi, Jeong Geun Kim, Mi Young Son, Donghee Ahn, Su Yeon J Clin Med Article In this study, we aimed to assess the prevalence of interstitial lung abnormalities (ILAs) and investigate the rates and risk factors associated with radiologic ILA progression among patients with lung cancer following surgical resection. Patients who underwent surgical resection for lung cancer at our institution from January 2015 to December 2020 were retrospectively evaluated and grouped according to their ILA status as having no ILAs, equivocal ILAs, or ILAs. Progression was determined by simultaneously reviewing the baseline and corresponding follow-up computed tomography (CT) scans. Among 346 patients (median age: 67 (interquartile range: 60–74) years, 204 (59.0%) men), 22 (6.4%) had equivocal ILAs, and 33 (9.5%) had ILAs detected upon baseline CT. Notably, six patients (6/291; 2.1%) without ILAs upon baseline CT later developed ILAs, and 50% (11/22) of those with equivocal ILAs exhibited progression. Furthermore, 75.8% (25/33) of patients with ILAs upon baseline CT exhibited ILA progression (76.9% and 71.4% with fibrotic and non-fibrotic ILAs, respectively). Multivariate analysis revealed that ILA status was a significant risk factor for ILA progression. ILAs and equivocal ILAs were associated with radiologic ILA progression after surgical resection in patients with lung cancer. Hence, early ILA detection can significantly affect clinical outcomes. MDPI 2023-10-30 /pmc/articles/PMC10647667/ /pubmed/37959324 http://dx.doi.org/10.3390/jcm12216858 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shin, Yoon Joo
Yi, Jeong Geun
Kim, Mi Young
Son, Donghee
Ahn, Su Yeon
Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer
title Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer
title_full Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer
title_fullStr Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer
title_full_unstemmed Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer
title_short Radiologic Progression of Interstitial Lung Abnormalities following Surgical Resection in Patients with Lung Cancer
title_sort radiologic progression of interstitial lung abnormalities following surgical resection in patients with lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647667/
https://www.ncbi.nlm.nih.gov/pubmed/37959324
http://dx.doi.org/10.3390/jcm12216858
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