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Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition

Tightly regulated and highly adaptive lipid metabolic and transport pathways are critical to maintaining brain cellular lipid homeostasis and responding to lipid and inflammatory stress to preserve brain function and health. Deficits in the lipid handling genes APOE and GBA1 are the most significant...

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Detalles Bibliográficos
Autores principales:	Connolly, Kyle J., Margaria, Juliette, Di Biase, Erika, Cooper, Oliver, Hallett, Penelope J., Isacson, Ole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647680/ https://www.ncbi.nlm.nih.gov/pubmed/37947642 http://dx.doi.org/10.3390/cells12212564

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