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Aza Analogs of the TRPML1 Inhibitor Estradiol Methyl Ether (EDME)
Estradiol methyl ether (EDME) has recently been described by us as a very potent and subtype-specific inhibitor of the lysosomal cation channel TRPML1. Following the principle of bioisosteres, we worked out efficient synthetic approaches to ring-A aza-analogs of EDME, namely a methoxypyridine and a...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647736/ https://www.ncbi.nlm.nih.gov/pubmed/37959848 http://dx.doi.org/10.3390/molecules28217428 |