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The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding

Nutritional support is essential for patients with severe motor and intellectual disabilities (SMID) to ensure the smooth provision of medical care. These patients often require long-term tube feeding with enteral formulas, potentially leading to deficiencies in vitamins and trace elements. Addition...

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Autores principales: Ohmori, Hiromitsu, Kato, Akihiko, Shirai, Yuka, Fukano, Reiji, Nagae, Akiko, Yamasaki, Masami, Komenaka, Junko, Imamura, Eiji, Kumode, Masao, Miyachi, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647752/
https://www.ncbi.nlm.nih.gov/pubmed/37960177
http://dx.doi.org/10.3390/nu15214525
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author Ohmori, Hiromitsu
Kato, Akihiko
Shirai, Yuka
Fukano, Reiji
Nagae, Akiko
Yamasaki, Masami
Komenaka, Junko
Imamura, Eiji
Kumode, Masao
Miyachi, Takafumi
author_facet Ohmori, Hiromitsu
Kato, Akihiko
Shirai, Yuka
Fukano, Reiji
Nagae, Akiko
Yamasaki, Masami
Komenaka, Junko
Imamura, Eiji
Kumode, Masao
Miyachi, Takafumi
author_sort Ohmori, Hiromitsu
collection PubMed
description Nutritional support is essential for patients with severe motor and intellectual disabilities (SMID) to ensure the smooth provision of medical care. These patients often require long-term tube feeding with enteral formulas, potentially leading to deficiencies in vitamins and trace elements. Additionally, frequent antibiotic use for infections often disrupts gut microbiota, inhibiting vitamin K2 production by intestinal bacteria. We assessed the serum protein induced by vitamin K absence or antagonists-II (PIVKA-II) and undercarboxylated osteocalcin (ucOC) levels to assess the vitamin K status in 20 patients with SMID (median age: 44.1 years, 11 men and 9 women) undergoing long-term tube feeding for durations ranging from 3 to 31 years. Thirteen (65%) and nine (45%) patients had elevated PIVKA-II (<40 mAU/mL) and serum ucOC levels (reference value < 4.50 ng/mL), respectively. Dietary vitamin K1 intake did not differ between patients with and without elevated PIVKA-II levels. Vitamin K2 supplementation for 3 months decreased serum PIVKA-II levels near those within the reference range. Approximately half of the patients with SMID on tube feeding had subclinical vitamin K deficiency. Further studies are needed to ascertain if long-term vitamin K2 supplementation effectively prevents vitamin K deficiency-induced hypercoagulation, osteoporosis, and vascular calcification in patients with SMID.
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spelling pubmed-106477522023-10-25 The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding Ohmori, Hiromitsu Kato, Akihiko Shirai, Yuka Fukano, Reiji Nagae, Akiko Yamasaki, Masami Komenaka, Junko Imamura, Eiji Kumode, Masao Miyachi, Takafumi Nutrients Article Nutritional support is essential for patients with severe motor and intellectual disabilities (SMID) to ensure the smooth provision of medical care. These patients often require long-term tube feeding with enteral formulas, potentially leading to deficiencies in vitamins and trace elements. Additionally, frequent antibiotic use for infections often disrupts gut microbiota, inhibiting vitamin K2 production by intestinal bacteria. We assessed the serum protein induced by vitamin K absence or antagonists-II (PIVKA-II) and undercarboxylated osteocalcin (ucOC) levels to assess the vitamin K status in 20 patients with SMID (median age: 44.1 years, 11 men and 9 women) undergoing long-term tube feeding for durations ranging from 3 to 31 years. Thirteen (65%) and nine (45%) patients had elevated PIVKA-II (<40 mAU/mL) and serum ucOC levels (reference value < 4.50 ng/mL), respectively. Dietary vitamin K1 intake did not differ between patients with and without elevated PIVKA-II levels. Vitamin K2 supplementation for 3 months decreased serum PIVKA-II levels near those within the reference range. Approximately half of the patients with SMID on tube feeding had subclinical vitamin K deficiency. Further studies are needed to ascertain if long-term vitamin K2 supplementation effectively prevents vitamin K deficiency-induced hypercoagulation, osteoporosis, and vascular calcification in patients with SMID. MDPI 2023-10-25 /pmc/articles/PMC10647752/ /pubmed/37960177 http://dx.doi.org/10.3390/nu15214525 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ohmori, Hiromitsu
Kato, Akihiko
Shirai, Yuka
Fukano, Reiji
Nagae, Akiko
Yamasaki, Masami
Komenaka, Junko
Imamura, Eiji
Kumode, Masao
Miyachi, Takafumi
The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding
title The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding
title_full The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding
title_fullStr The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding
title_full_unstemmed The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding
title_short The Effect of Vitamin K2 Supplementation on PIVKA-II Levels in Patients with Severe Motor and Intellectual Disabilities Undergoing Long-Term Tube Feeding
title_sort effect of vitamin k2 supplementation on pivka-ii levels in patients with severe motor and intellectual disabilities undergoing long-term tube feeding
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647752/
https://www.ncbi.nlm.nih.gov/pubmed/37960177
http://dx.doi.org/10.3390/nu15214525
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