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Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study
(1) Background: The “obesity paradox” refers to a protective effect of higher body mass index (BMI) on mortality in acute infectious disease patients. However, the long-term impact of this paradox remains uncertain. (2) Methods: A retrospective study of patients diagnosed with community-acquired acu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647762/ https://www.ncbi.nlm.nih.gov/pubmed/37959230 http://dx.doi.org/10.3390/jcm12216765 |
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author | Elkan, Matan Kofman, Natalia Minha, Sa’ar Rappoport, Nadav Zaidenstein, Ronit Koren, Ronit |
author_facet | Elkan, Matan Kofman, Natalia Minha, Sa’ar Rappoport, Nadav Zaidenstein, Ronit Koren, Ronit |
author_sort | Elkan, Matan |
collection | PubMed |
description | (1) Background: The “obesity paradox” refers to a protective effect of higher body mass index (BMI) on mortality in acute infectious disease patients. However, the long-term impact of this paradox remains uncertain. (2) Methods: A retrospective study of patients diagnosed with community-acquired acute infectious diseases at Shamir Medical Center, Israel (2010–2020) was conducted. Patients were grouped by BMI: underweight, normal weight, overweight, and obesity classes I–III. Short- and long-term mortality rates were compared across these groups. (3) Results: Of the 25,226 patients, diverse demographics and comorbidities were observed across BMI categories. Short-term (90-day) and long-term (one-year) mortality rates were notably higher in underweight and normal-weight groups compared to others. Specifically, 90-day mortality was 22% and 13.2% for underweight and normal weight respectively, versus 7–9% for others (p < 0.001). Multivariate time series analysis revealed underweight individuals had a significantly higher 5-year mortality risk (HR 1.41 (95% CI 1.27–1.58, p < 0.001)), while overweight and obese categories had a reduced risk (overweight—HR 0.76 (95% CI 0.72–0.80, p < 0.001), obesity class I—HR 0.71 (95% CI 0.66–0.76, p < 0.001), obesity class II—HR 0.77 (95% CI 0.70–0.85, p < 0.001), and obesity class III—HR 0.79 (95% CI 0.67–0.92, p = 0.003)). (4) Conclusions: In this comprehensive study, obesity was independently associated with decreased short- and long-term mortality. These unexpected results prompt further exploration of this counterintuitive phenomenon. |
format | Online Article Text |
id | pubmed-10647762 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106477622023-10-26 Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study Elkan, Matan Kofman, Natalia Minha, Sa’ar Rappoport, Nadav Zaidenstein, Ronit Koren, Ronit J Clin Med Article (1) Background: The “obesity paradox” refers to a protective effect of higher body mass index (BMI) on mortality in acute infectious disease patients. However, the long-term impact of this paradox remains uncertain. (2) Methods: A retrospective study of patients diagnosed with community-acquired acute infectious diseases at Shamir Medical Center, Israel (2010–2020) was conducted. Patients were grouped by BMI: underweight, normal weight, overweight, and obesity classes I–III. Short- and long-term mortality rates were compared across these groups. (3) Results: Of the 25,226 patients, diverse demographics and comorbidities were observed across BMI categories. Short-term (90-day) and long-term (one-year) mortality rates were notably higher in underweight and normal-weight groups compared to others. Specifically, 90-day mortality was 22% and 13.2% for underweight and normal weight respectively, versus 7–9% for others (p < 0.001). Multivariate time series analysis revealed underweight individuals had a significantly higher 5-year mortality risk (HR 1.41 (95% CI 1.27–1.58, p < 0.001)), while overweight and obese categories had a reduced risk (overweight—HR 0.76 (95% CI 0.72–0.80, p < 0.001), obesity class I—HR 0.71 (95% CI 0.66–0.76, p < 0.001), obesity class II—HR 0.77 (95% CI 0.70–0.85, p < 0.001), and obesity class III—HR 0.79 (95% CI 0.67–0.92, p = 0.003)). (4) Conclusions: In this comprehensive study, obesity was independently associated with decreased short- and long-term mortality. These unexpected results prompt further exploration of this counterintuitive phenomenon. MDPI 2023-10-26 /pmc/articles/PMC10647762/ /pubmed/37959230 http://dx.doi.org/10.3390/jcm12216765 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Elkan, Matan Kofman, Natalia Minha, Sa’ar Rappoport, Nadav Zaidenstein, Ronit Koren, Ronit Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study |
title | Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study |
title_full | Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study |
title_fullStr | Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study |
title_full_unstemmed | Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study |
title_short | Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study |
title_sort | does the “obesity paradox” have an expiration date? a retrospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647762/ https://www.ncbi.nlm.nih.gov/pubmed/37959230 http://dx.doi.org/10.3390/jcm12216765 |
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