Cargando…

Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study

(1) Background: The “obesity paradox” refers to a protective effect of higher body mass index (BMI) on mortality in acute infectious disease patients. However, the long-term impact of this paradox remains uncertain. (2) Methods: A retrospective study of patients diagnosed with community-acquired acu...

Descripción completa

Detalles Bibliográficos
Autores principales: Elkan, Matan, Kofman, Natalia, Minha, Sa’ar, Rappoport, Nadav, Zaidenstein, Ronit, Koren, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647762/
https://www.ncbi.nlm.nih.gov/pubmed/37959230
http://dx.doi.org/10.3390/jcm12216765
_version_ 1785135183781953536
author Elkan, Matan
Kofman, Natalia
Minha, Sa’ar
Rappoport, Nadav
Zaidenstein, Ronit
Koren, Ronit
author_facet Elkan, Matan
Kofman, Natalia
Minha, Sa’ar
Rappoport, Nadav
Zaidenstein, Ronit
Koren, Ronit
author_sort Elkan, Matan
collection PubMed
description (1) Background: The “obesity paradox” refers to a protective effect of higher body mass index (BMI) on mortality in acute infectious disease patients. However, the long-term impact of this paradox remains uncertain. (2) Methods: A retrospective study of patients diagnosed with community-acquired acute infectious diseases at Shamir Medical Center, Israel (2010–2020) was conducted. Patients were grouped by BMI: underweight, normal weight, overweight, and obesity classes I–III. Short- and long-term mortality rates were compared across these groups. (3) Results: Of the 25,226 patients, diverse demographics and comorbidities were observed across BMI categories. Short-term (90-day) and long-term (one-year) mortality rates were notably higher in underweight and normal-weight groups compared to others. Specifically, 90-day mortality was 22% and 13.2% for underweight and normal weight respectively, versus 7–9% for others (p < 0.001). Multivariate time series analysis revealed underweight individuals had a significantly higher 5-year mortality risk (HR 1.41 (95% CI 1.27–1.58, p < 0.001)), while overweight and obese categories had a reduced risk (overweight—HR 0.76 (95% CI 0.72–0.80, p < 0.001), obesity class I—HR 0.71 (95% CI 0.66–0.76, p < 0.001), obesity class II—HR 0.77 (95% CI 0.70–0.85, p < 0.001), and obesity class III—HR 0.79 (95% CI 0.67–0.92, p = 0.003)). (4) Conclusions: In this comprehensive study, obesity was independently associated with decreased short- and long-term mortality. These unexpected results prompt further exploration of this counterintuitive phenomenon.
format Online
Article
Text
id pubmed-10647762
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106477622023-10-26 Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study Elkan, Matan Kofman, Natalia Minha, Sa’ar Rappoport, Nadav Zaidenstein, Ronit Koren, Ronit J Clin Med Article (1) Background: The “obesity paradox” refers to a protective effect of higher body mass index (BMI) on mortality in acute infectious disease patients. However, the long-term impact of this paradox remains uncertain. (2) Methods: A retrospective study of patients diagnosed with community-acquired acute infectious diseases at Shamir Medical Center, Israel (2010–2020) was conducted. Patients were grouped by BMI: underweight, normal weight, overweight, and obesity classes I–III. Short- and long-term mortality rates were compared across these groups. (3) Results: Of the 25,226 patients, diverse demographics and comorbidities were observed across BMI categories. Short-term (90-day) and long-term (one-year) mortality rates were notably higher in underweight and normal-weight groups compared to others. Specifically, 90-day mortality was 22% and 13.2% for underweight and normal weight respectively, versus 7–9% for others (p < 0.001). Multivariate time series analysis revealed underweight individuals had a significantly higher 5-year mortality risk (HR 1.41 (95% CI 1.27–1.58, p < 0.001)), while overweight and obese categories had a reduced risk (overweight—HR 0.76 (95% CI 0.72–0.80, p < 0.001), obesity class I—HR 0.71 (95% CI 0.66–0.76, p < 0.001), obesity class II—HR 0.77 (95% CI 0.70–0.85, p < 0.001), and obesity class III—HR 0.79 (95% CI 0.67–0.92, p = 0.003)). (4) Conclusions: In this comprehensive study, obesity was independently associated with decreased short- and long-term mortality. These unexpected results prompt further exploration of this counterintuitive phenomenon. MDPI 2023-10-26 /pmc/articles/PMC10647762/ /pubmed/37959230 http://dx.doi.org/10.3390/jcm12216765 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elkan, Matan
Kofman, Natalia
Minha, Sa’ar
Rappoport, Nadav
Zaidenstein, Ronit
Koren, Ronit
Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study
title Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study
title_full Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study
title_fullStr Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study
title_full_unstemmed Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study
title_short Does the “Obesity Paradox” Have an Expiration Date? A Retrospective Cohort Study
title_sort does the “obesity paradox” have an expiration date? a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647762/
https://www.ncbi.nlm.nih.gov/pubmed/37959230
http://dx.doi.org/10.3390/jcm12216765
work_keys_str_mv AT elkanmatan doestheobesityparadoxhaveanexpirationdatearetrospectivecohortstudy
AT kofmannatalia doestheobesityparadoxhaveanexpirationdatearetrospectivecohortstudy
AT minhasaar doestheobesityparadoxhaveanexpirationdatearetrospectivecohortstudy
AT rappoportnadav doestheobesityparadoxhaveanexpirationdatearetrospectivecohortstudy
AT zaidensteinronit doestheobesityparadoxhaveanexpirationdatearetrospectivecohortstudy
AT korenronit doestheobesityparadoxhaveanexpirationdatearetrospectivecohortstudy