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Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure
Background: Galectin-3 (Gal-3) is a biomarker involved in a wide range of diseases including cardiac remodeling following acute myocardial infarction (AMI). Identification of prognostic markers in patients with AMI can guide strategies towards improved survival and quality of life. Methods: Our stud...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647840/ https://www.ncbi.nlm.nih.gov/pubmed/37958244 http://dx.doi.org/10.3390/diagnostics13213348 |
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author | Vucic, Rada M. Andrejic, Olivera M. Stokanovic, Dragana Stoimenov, Tatjana Jevtovic McClements, Lana Nikolic, Valentina N. Sreckovic, Miodrag Veselinovic, Mirjana Aleksandric, Srdjan Popadic, Viseslav Zdravkovic, Marija Pavlovic, Milan |
author_facet | Vucic, Rada M. Andrejic, Olivera M. Stokanovic, Dragana Stoimenov, Tatjana Jevtovic McClements, Lana Nikolic, Valentina N. Sreckovic, Miodrag Veselinovic, Mirjana Aleksandric, Srdjan Popadic, Viseslav Zdravkovic, Marija Pavlovic, Milan |
author_sort | Vucic, Rada M. |
collection | PubMed |
description | Background: Galectin-3 (Gal-3) is a biomarker involved in a wide range of diseases including cardiac remodeling following acute myocardial infarction (AMI). Identification of prognostic markers in patients with AMI can guide strategies towards improved survival and quality of life. Methods: Our study included 59 patients with AMI and a preserved ejection fraction. We determined the Gal-3 plasma concentration within 24 h of chest pain onset from the aortic root, femoral/radial artery, coronary sinus and cubital vein. Major adverse cardiovascular events (MACEs) were evaluated at six months follow-up. Results: MACE at six months post-AMI was recorded in 20 patients (34%). The Gal-3 plasma concentration from the aortic root and the femoral/radial artery were independent predictors of MACE at six months follow-up after the first AMI (OR 1.228; 95%CI: 1.011–1.491; p = 0.038; OR 3.438; 95%CI: 1.275–9.265; p = 0.015). ROC analysis identifies the Gal-3 plasma concentration from the aortic root as a better predictor of MACE or death (cut-off ≥ 10.86 ng/mL; AUC 0.858; 95%CI: 0.744–0.973; p < 0.001) than Gal-3 plasma concentration from the femoral/radial artery (cut-off ≥ 10.18 ng/mL; AUC 0.742; 95%CI: 0.596–0.888; p = 0.006). Conclusion: the Gal-3 plasma concentration in patients with AMI determined during coronary angiography, especially from the aortic root, within 24 h after chest pain onset is a valuable biomarker of prognosis at six months follow-up. |
format | Online Article Text |
id | pubmed-10647840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106478402023-10-31 Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure Vucic, Rada M. Andrejic, Olivera M. Stokanovic, Dragana Stoimenov, Tatjana Jevtovic McClements, Lana Nikolic, Valentina N. Sreckovic, Miodrag Veselinovic, Mirjana Aleksandric, Srdjan Popadic, Viseslav Zdravkovic, Marija Pavlovic, Milan Diagnostics (Basel) Article Background: Galectin-3 (Gal-3) is a biomarker involved in a wide range of diseases including cardiac remodeling following acute myocardial infarction (AMI). Identification of prognostic markers in patients with AMI can guide strategies towards improved survival and quality of life. Methods: Our study included 59 patients with AMI and a preserved ejection fraction. We determined the Gal-3 plasma concentration within 24 h of chest pain onset from the aortic root, femoral/radial artery, coronary sinus and cubital vein. Major adverse cardiovascular events (MACEs) were evaluated at six months follow-up. Results: MACE at six months post-AMI was recorded in 20 patients (34%). The Gal-3 plasma concentration from the aortic root and the femoral/radial artery were independent predictors of MACE at six months follow-up after the first AMI (OR 1.228; 95%CI: 1.011–1.491; p = 0.038; OR 3.438; 95%CI: 1.275–9.265; p = 0.015). ROC analysis identifies the Gal-3 plasma concentration from the aortic root as a better predictor of MACE or death (cut-off ≥ 10.86 ng/mL; AUC 0.858; 95%CI: 0.744–0.973; p < 0.001) than Gal-3 plasma concentration from the femoral/radial artery (cut-off ≥ 10.18 ng/mL; AUC 0.742; 95%CI: 0.596–0.888; p = 0.006). Conclusion: the Gal-3 plasma concentration in patients with AMI determined during coronary angiography, especially from the aortic root, within 24 h after chest pain onset is a valuable biomarker of prognosis at six months follow-up. MDPI 2023-10-31 /pmc/articles/PMC10647840/ /pubmed/37958244 http://dx.doi.org/10.3390/diagnostics13213348 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vucic, Rada M. Andrejic, Olivera M. Stokanovic, Dragana Stoimenov, Tatjana Jevtovic McClements, Lana Nikolic, Valentina N. Sreckovic, Miodrag Veselinovic, Mirjana Aleksandric, Srdjan Popadic, Viseslav Zdravkovic, Marija Pavlovic, Milan Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure |
title | Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure |
title_full | Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure |
title_fullStr | Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure |
title_full_unstemmed | Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure |
title_short | Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure |
title_sort | galectin-3 as a prognostic biomarker in patients with first acute myocardial infarction without heart failure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647840/ https://www.ncbi.nlm.nih.gov/pubmed/37958244 http://dx.doi.org/10.3390/diagnostics13213348 |
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