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Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)

Cancer presents a formidable threat to human health, with the majority of cases currently lacking a complete cure. Frequently, chemotherapy drugs are required to impede its progression. However, these drugs frequently suffer from drawbacks such as poor selectivity, limited water solubility, low bioa...

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Autores principales: Wang, Zongheng, Xiao, Miaomiao, Guo, Fangliang, Yan, Yue, Tian, Hong, Zhang, Qianshi, Ren, Shuangyi, Yang, Liqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647934/
https://www.ncbi.nlm.nih.gov/pubmed/38026861
http://dx.doi.org/10.3389/fbioe.2023.1295323
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author Wang, Zongheng
Xiao, Miaomiao
Guo, Fangliang
Yan, Yue
Tian, Hong
Zhang, Qianshi
Ren, Shuangyi
Yang, Liqun
author_facet Wang, Zongheng
Xiao, Miaomiao
Guo, Fangliang
Yan, Yue
Tian, Hong
Zhang, Qianshi
Ren, Shuangyi
Yang, Liqun
author_sort Wang, Zongheng
collection PubMed
description Cancer presents a formidable threat to human health, with the majority of cases currently lacking a complete cure. Frequently, chemotherapy drugs are required to impede its progression. However, these drugs frequently suffer from drawbacks such as poor selectivity, limited water solubility, low bioavailability, and a propensity for causing organ toxicity. Consequently, a concerted effort has been made to seek improved drug delivery systems. Nano-drug delivery systems based on biodegradable polyesters have emerged as a subject of widespread interest in this pursuit. Extensive research has demonstrated their potential for offering high bioavailability, effective encapsulation, controlled release, and minimal toxicity. Notably, poly (ε-caprolactone) (PCL), poly (lactic-co-glycolic acid) (PLGA), and polylactic acid (PLA) have gained prominence as the most widely utilized options as carriers of the nano drug delivery system. This paper comprehensively reviews recent research on these materials as nano-carriers for delivering chemotherapeutic drugs, summarizing their latest advancements, acknowledging their limitations, and forecasting future research directions.
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spelling pubmed-106479342023-01-01 Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023) Wang, Zongheng Xiao, Miaomiao Guo, Fangliang Yan, Yue Tian, Hong Zhang, Qianshi Ren, Shuangyi Yang, Liqun Front Bioeng Biotechnol Bioengineering and Biotechnology Cancer presents a formidable threat to human health, with the majority of cases currently lacking a complete cure. Frequently, chemotherapy drugs are required to impede its progression. However, these drugs frequently suffer from drawbacks such as poor selectivity, limited water solubility, low bioavailability, and a propensity for causing organ toxicity. Consequently, a concerted effort has been made to seek improved drug delivery systems. Nano-drug delivery systems based on biodegradable polyesters have emerged as a subject of widespread interest in this pursuit. Extensive research has demonstrated their potential for offering high bioavailability, effective encapsulation, controlled release, and minimal toxicity. Notably, poly (ε-caprolactone) (PCL), poly (lactic-co-glycolic acid) (PLGA), and polylactic acid (PLA) have gained prominence as the most widely utilized options as carriers of the nano drug delivery system. This paper comprehensively reviews recent research on these materials as nano-carriers for delivering chemotherapeutic drugs, summarizing their latest advancements, acknowledging their limitations, and forecasting future research directions. Frontiers Media S.A. 2023-11-01 /pmc/articles/PMC10647934/ /pubmed/38026861 http://dx.doi.org/10.3389/fbioe.2023.1295323 Text en Copyright © 2023 Wang, Xiao, Guo, Yan, Tian, Zhang, Ren and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Wang, Zongheng
Xiao, Miaomiao
Guo, Fangliang
Yan, Yue
Tian, Hong
Zhang, Qianshi
Ren, Shuangyi
Yang, Liqun
Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)
title Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)
title_full Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)
title_fullStr Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)
title_full_unstemmed Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)
title_short Biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)
title_sort biodegradable polyester-based nano drug delivery system in cancer chemotherapy: a review of recent progress (2021–2023)
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10647934/
https://www.ncbi.nlm.nih.gov/pubmed/38026861
http://dx.doi.org/10.3389/fbioe.2023.1295323
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