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Natural Chalcones for the Management of Obesity Disease
In the last decade, the incidence of obesity has increased dramatically worldwide, reaching a dangerous pandemic spread. This condition has serious public health implications as it significantly increases the risk of chronic diseases such as type 2 diabetes, fatty liver, hypertension, heart attack,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648025/ https://www.ncbi.nlm.nih.gov/pubmed/37958912 http://dx.doi.org/10.3390/ijms242115929 |
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author | Maisto, Maria Marzocchi, Adua Keivani, Niloufar Piccolo, Vincenzo Summa, Vincenzo Tenore, Gian Carlo |
author_facet | Maisto, Maria Marzocchi, Adua Keivani, Niloufar Piccolo, Vincenzo Summa, Vincenzo Tenore, Gian Carlo |
author_sort | Maisto, Maria |
collection | PubMed |
description | In the last decade, the incidence of obesity has increased dramatically worldwide, reaching a dangerous pandemic spread. This condition has serious public health implications as it significantly increases the risk of chronic diseases such as type 2 diabetes, fatty liver, hypertension, heart attack, and stroke. The treatment of obesity is therefore the greatest health challenge of our time. Conventional therapeutic treatment of obesity is based on the use of various synthetic molecules belonging to the class of appetite suppressants, lipase inhibitors, hormones, metabolic regulators, and inhibitors of intestinal peptide receptors. The long-term use of these molecules is generally limited by various side effects and tolerance. For this reason, the search for natural alternatives to treat obesity is a current research goal. This review therefore examined the anti-obesity potential of natural chalcones based on available evidence from in vitro and animal studies. In particular, the results of the main in vitro studies describing the principal molecular therapeutic targets and the mechanism of action of the different chalcones investigated were described. In addition, the results of the most relevant animal studies were reported. Undoubtedly, future clinical studies are urgently needed to confirm and validate the potential of natural chalcones in the clinical prophylaxis of obesity. |
format | Online Article Text |
id | pubmed-10648025 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106480252023-11-03 Natural Chalcones for the Management of Obesity Disease Maisto, Maria Marzocchi, Adua Keivani, Niloufar Piccolo, Vincenzo Summa, Vincenzo Tenore, Gian Carlo Int J Mol Sci Review In the last decade, the incidence of obesity has increased dramatically worldwide, reaching a dangerous pandemic spread. This condition has serious public health implications as it significantly increases the risk of chronic diseases such as type 2 diabetes, fatty liver, hypertension, heart attack, and stroke. The treatment of obesity is therefore the greatest health challenge of our time. Conventional therapeutic treatment of obesity is based on the use of various synthetic molecules belonging to the class of appetite suppressants, lipase inhibitors, hormones, metabolic regulators, and inhibitors of intestinal peptide receptors. The long-term use of these molecules is generally limited by various side effects and tolerance. For this reason, the search for natural alternatives to treat obesity is a current research goal. This review therefore examined the anti-obesity potential of natural chalcones based on available evidence from in vitro and animal studies. In particular, the results of the main in vitro studies describing the principal molecular therapeutic targets and the mechanism of action of the different chalcones investigated were described. In addition, the results of the most relevant animal studies were reported. Undoubtedly, future clinical studies are urgently needed to confirm and validate the potential of natural chalcones in the clinical prophylaxis of obesity. MDPI 2023-11-03 /pmc/articles/PMC10648025/ /pubmed/37958912 http://dx.doi.org/10.3390/ijms242115929 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Maisto, Maria Marzocchi, Adua Keivani, Niloufar Piccolo, Vincenzo Summa, Vincenzo Tenore, Gian Carlo Natural Chalcones for the Management of Obesity Disease |
title | Natural Chalcones for the Management of Obesity Disease |
title_full | Natural Chalcones for the Management of Obesity Disease |
title_fullStr | Natural Chalcones for the Management of Obesity Disease |
title_full_unstemmed | Natural Chalcones for the Management of Obesity Disease |
title_short | Natural Chalcones for the Management of Obesity Disease |
title_sort | natural chalcones for the management of obesity disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648025/ https://www.ncbi.nlm.nih.gov/pubmed/37958912 http://dx.doi.org/10.3390/ijms242115929 |
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