Arthproliferins A–D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221

Four new sesterterpenes, arthproliferins A–D (1–4), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS)...

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Detalles Bibliográficos
Autores principales: Yang, Bin, Li, Cuitian, Chen, Ying, He, Yanchun, She, Jianglian, Zhou, Xuefeng, Tao, Huangming, Peng, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648114/
https://www.ncbi.nlm.nih.gov/pubmed/37959666
http://dx.doi.org/10.3390/molecules28217246
Descripción
Sumario:Four new sesterterpenes, arthproliferins A–D (1–4), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. Some of the isolated compounds were evaluated for their cytotoxicity in vitro. The results revealed that terpestacin (6) exhibited significant activity with an IC(50) value of 20.3 μM, and compounds 2 and 5 were found to show weak inhibitory effects against U87MG-derived GSCs.

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