Cargando…

Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives

Underactive bladder (UAB) is a prevalent but under-researched lower urinary tract symptom that typically occurs alongside detrusor underactivity (DU). Unlike UAB, DU is a urodynamic diagnosis which the International Continence Society (ICS) defines as “a contraction of reduced strength and/or durati...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jiaxin, Ren, Lida, Liu, Xinqi, Liu, Jihong, Ling, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648240/
https://www.ncbi.nlm.nih.gov/pubmed/37958499
http://dx.doi.org/10.3390/ijms242115517
_version_ 1785135294311301120
author Wang, Jiaxin
Ren, Lida
Liu, Xinqi
Liu, Jihong
Ling, Qing
author_facet Wang, Jiaxin
Ren, Lida
Liu, Xinqi
Liu, Jihong
Ling, Qing
author_sort Wang, Jiaxin
collection PubMed
description Underactive bladder (UAB) is a prevalent but under-researched lower urinary tract symptom that typically occurs alongside detrusor underactivity (DU). Unlike UAB, DU is a urodynamic diagnosis which the International Continence Society (ICS) defines as “a contraction of reduced strength and/or duration, resulting in prolonged bladder emptying and/or a failure to achieve complete bladder emptying within a normal time span”. Despite the widespread prevalence of UAB/DU, there are significant gaps in our understanding of its pathophysiological mechanisms, diagnosis, and treatment compared with overactive bladder (OAB) and detrusor overactivity (DO). These gaps are such that clinicians regard UAB/DU as an incurable condition. In recent years, the understanding of UAB has increased. The definition of UAB has been clarified, and the diagnostic criteria for DU have been considered more comprehensively. Meanwhile, a number of non-invasive diagnostic methods have also been reported. Clinical trials involving novel drugs, electrical stimulation, and stem cell therapy have shown promising results. Therefore, this review summarizes recent reports on UAB and DU and highlights the latest advances in their diagnosis and treatment.
format Online
Article
Text
id pubmed-10648240
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106482402023-10-24 Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives Wang, Jiaxin Ren, Lida Liu, Xinqi Liu, Jihong Ling, Qing Int J Mol Sci Review Underactive bladder (UAB) is a prevalent but under-researched lower urinary tract symptom that typically occurs alongside detrusor underactivity (DU). Unlike UAB, DU is a urodynamic diagnosis which the International Continence Society (ICS) defines as “a contraction of reduced strength and/or duration, resulting in prolonged bladder emptying and/or a failure to achieve complete bladder emptying within a normal time span”. Despite the widespread prevalence of UAB/DU, there are significant gaps in our understanding of its pathophysiological mechanisms, diagnosis, and treatment compared with overactive bladder (OAB) and detrusor overactivity (DO). These gaps are such that clinicians regard UAB/DU as an incurable condition. In recent years, the understanding of UAB has increased. The definition of UAB has been clarified, and the diagnostic criteria for DU have been considered more comprehensively. Meanwhile, a number of non-invasive diagnostic methods have also been reported. Clinical trials involving novel drugs, electrical stimulation, and stem cell therapy have shown promising results. Therefore, this review summarizes recent reports on UAB and DU and highlights the latest advances in their diagnosis and treatment. MDPI 2023-10-24 /pmc/articles/PMC10648240/ /pubmed/37958499 http://dx.doi.org/10.3390/ijms242115517 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Jiaxin
Ren, Lida
Liu, Xinqi
Liu, Jihong
Ling, Qing
Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives
title Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives
title_full Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives
title_fullStr Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives
title_full_unstemmed Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives
title_short Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives
title_sort underactive bladder and detrusor underactivity: new advances and prospectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648240/
https://www.ncbi.nlm.nih.gov/pubmed/37958499
http://dx.doi.org/10.3390/ijms242115517
work_keys_str_mv AT wangjiaxin underactivebladderanddetrusorunderactivitynewadvancesandprospectives
AT renlida underactivebladderanddetrusorunderactivitynewadvancesandprospectives
AT liuxinqi underactivebladderanddetrusorunderactivitynewadvancesandprospectives
AT liujihong underactivebladderanddetrusorunderactivitynewadvancesandprospectives
AT lingqing underactivebladderanddetrusorunderactivitynewadvancesandprospectives