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Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives
Underactive bladder (UAB) is a prevalent but under-researched lower urinary tract symptom that typically occurs alongside detrusor underactivity (DU). Unlike UAB, DU is a urodynamic diagnosis which the International Continence Society (ICS) defines as “a contraction of reduced strength and/or durati...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648240/ https://www.ncbi.nlm.nih.gov/pubmed/37958499 http://dx.doi.org/10.3390/ijms242115517 |
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author | Wang, Jiaxin Ren, Lida Liu, Xinqi Liu, Jihong Ling, Qing |
author_facet | Wang, Jiaxin Ren, Lida Liu, Xinqi Liu, Jihong Ling, Qing |
author_sort | Wang, Jiaxin |
collection | PubMed |
description | Underactive bladder (UAB) is a prevalent but under-researched lower urinary tract symptom that typically occurs alongside detrusor underactivity (DU). Unlike UAB, DU is a urodynamic diagnosis which the International Continence Society (ICS) defines as “a contraction of reduced strength and/or duration, resulting in prolonged bladder emptying and/or a failure to achieve complete bladder emptying within a normal time span”. Despite the widespread prevalence of UAB/DU, there are significant gaps in our understanding of its pathophysiological mechanisms, diagnosis, and treatment compared with overactive bladder (OAB) and detrusor overactivity (DO). These gaps are such that clinicians regard UAB/DU as an incurable condition. In recent years, the understanding of UAB has increased. The definition of UAB has been clarified, and the diagnostic criteria for DU have been considered more comprehensively. Meanwhile, a number of non-invasive diagnostic methods have also been reported. Clinical trials involving novel drugs, electrical stimulation, and stem cell therapy have shown promising results. Therefore, this review summarizes recent reports on UAB and DU and highlights the latest advances in their diagnosis and treatment. |
format | Online Article Text |
id | pubmed-10648240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106482402023-10-24 Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives Wang, Jiaxin Ren, Lida Liu, Xinqi Liu, Jihong Ling, Qing Int J Mol Sci Review Underactive bladder (UAB) is a prevalent but under-researched lower urinary tract symptom that typically occurs alongside detrusor underactivity (DU). Unlike UAB, DU is a urodynamic diagnosis which the International Continence Society (ICS) defines as “a contraction of reduced strength and/or duration, resulting in prolonged bladder emptying and/or a failure to achieve complete bladder emptying within a normal time span”. Despite the widespread prevalence of UAB/DU, there are significant gaps in our understanding of its pathophysiological mechanisms, diagnosis, and treatment compared with overactive bladder (OAB) and detrusor overactivity (DO). These gaps are such that clinicians regard UAB/DU as an incurable condition. In recent years, the understanding of UAB has increased. The definition of UAB has been clarified, and the diagnostic criteria for DU have been considered more comprehensively. Meanwhile, a number of non-invasive diagnostic methods have also been reported. Clinical trials involving novel drugs, electrical stimulation, and stem cell therapy have shown promising results. Therefore, this review summarizes recent reports on UAB and DU and highlights the latest advances in their diagnosis and treatment. MDPI 2023-10-24 /pmc/articles/PMC10648240/ /pubmed/37958499 http://dx.doi.org/10.3390/ijms242115517 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Jiaxin Ren, Lida Liu, Xinqi Liu, Jihong Ling, Qing Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives |
title | Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives |
title_full | Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives |
title_fullStr | Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives |
title_full_unstemmed | Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives |
title_short | Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives |
title_sort | underactive bladder and detrusor underactivity: new advances and prospectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648240/ https://www.ncbi.nlm.nih.gov/pubmed/37958499 http://dx.doi.org/10.3390/ijms242115517 |
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