Cargando…
Altered plasma protein profiles in genetic FTD – a GENFI study
BACKGROUND: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple pla...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648335/ https://www.ncbi.nlm.nih.gov/pubmed/37968725 http://dx.doi.org/10.1186/s13024-023-00677-6 |
_version_ | 1785147538313052160 |
---|---|
author | Ullgren, Abbe Öijerstedt, Linn Olofsson, Jennie Bergström, Sofia Remnestål, Julia van Swieten, John C. Jiskoot, Lize C. Seelaar, Harro Borroni, Barbara Sanchez-Valle, Raquel Moreno, Fermin Laforce, Robert Synofzik, Matthis Galimberti, Daniela Rowe, James B. Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik de Mendonça, Alexandre Tirabosch, Pietro Santana, Isabel Ducharme, Simon Butler, Chris R. Gerhard, Alexander Otto, Markus Bouzigues, Arabella Russell, Lucy Swift, Imogen J. Sogorb-Esteve, Aitana Heller, Carolin Rohrer, Jonathan D. Månberg, Anna Nilsson, Peter Graff, Caroline |
author_facet | Ullgren, Abbe Öijerstedt, Linn Olofsson, Jennie Bergström, Sofia Remnestål, Julia van Swieten, John C. Jiskoot, Lize C. Seelaar, Harro Borroni, Barbara Sanchez-Valle, Raquel Moreno, Fermin Laforce, Robert Synofzik, Matthis Galimberti, Daniela Rowe, James B. Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik de Mendonça, Alexandre Tirabosch, Pietro Santana, Isabel Ducharme, Simon Butler, Chris R. Gerhard, Alexander Otto, Markus Bouzigues, Arabella Russell, Lucy Swift, Imogen J. Sogorb-Esteve, Aitana Heller, Carolin Rohrer, Jonathan D. Månberg, Anna Nilsson, Peter Graff, Caroline |
author_sort | Ullgren, Abbe |
collection | PubMed |
description | BACKGROUND: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. METHODS: Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins. RESULTS: We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers. CONCLUSION: We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13024-023-00677-6. |
format | Online Article Text |
id | pubmed-10648335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106483352023-11-15 Altered plasma protein profiles in genetic FTD – a GENFI study Ullgren, Abbe Öijerstedt, Linn Olofsson, Jennie Bergström, Sofia Remnestål, Julia van Swieten, John C. Jiskoot, Lize C. Seelaar, Harro Borroni, Barbara Sanchez-Valle, Raquel Moreno, Fermin Laforce, Robert Synofzik, Matthis Galimberti, Daniela Rowe, James B. Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik de Mendonça, Alexandre Tirabosch, Pietro Santana, Isabel Ducharme, Simon Butler, Chris R. Gerhard, Alexander Otto, Markus Bouzigues, Arabella Russell, Lucy Swift, Imogen J. Sogorb-Esteve, Aitana Heller, Carolin Rohrer, Jonathan D. Månberg, Anna Nilsson, Peter Graff, Caroline Mol Neurodegener Research Article BACKGROUND: Plasma biomarkers reflecting the pathology of frontotemporal dementia would add significant value to clinical practice, to the design and implementation of treatment trials as well as our understanding of disease mechanisms. The aim of this study was to explore the levels of multiple plasma proteins in individuals from families with genetic frontotemporal dementia. METHODS: Blood samples from 693 participants in the GENetic Frontotemporal Dementia Initiative study were analysed using a multiplexed antibody array targeting 158 proteins. RESULTS: We found 13 elevated proteins in symptomatic mutation carriers, when comparing plasma levels from people diagnosed with genetic FTD to healthy non-mutation controls and 10 proteins that were elevated compared to presymptomatic mutation carriers. CONCLUSION: We identified plasma proteins with altered levels in symptomatic mutation carriers compared to non-carrier controls as well as to presymptomatic mutation carriers. Further investigations are needed to elucidate their potential as fluid biomarkers of the disease process. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13024-023-00677-6. BioMed Central 2023-11-15 /pmc/articles/PMC10648335/ /pubmed/37968725 http://dx.doi.org/10.1186/s13024-023-00677-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Ullgren, Abbe Öijerstedt, Linn Olofsson, Jennie Bergström, Sofia Remnestål, Julia van Swieten, John C. Jiskoot, Lize C. Seelaar, Harro Borroni, Barbara Sanchez-Valle, Raquel Moreno, Fermin Laforce, Robert Synofzik, Matthis Galimberti, Daniela Rowe, James B. Masellis, Mario Tartaglia, Maria Carmela Finger, Elizabeth Vandenberghe, Rik de Mendonça, Alexandre Tirabosch, Pietro Santana, Isabel Ducharme, Simon Butler, Chris R. Gerhard, Alexander Otto, Markus Bouzigues, Arabella Russell, Lucy Swift, Imogen J. Sogorb-Esteve, Aitana Heller, Carolin Rohrer, Jonathan D. Månberg, Anna Nilsson, Peter Graff, Caroline Altered plasma protein profiles in genetic FTD – a GENFI study |
title | Altered plasma protein profiles in genetic FTD – a GENFI study |
title_full | Altered plasma protein profiles in genetic FTD – a GENFI study |
title_fullStr | Altered plasma protein profiles in genetic FTD – a GENFI study |
title_full_unstemmed | Altered plasma protein profiles in genetic FTD – a GENFI study |
title_short | Altered plasma protein profiles in genetic FTD – a GENFI study |
title_sort | altered plasma protein profiles in genetic ftd – a genfi study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648335/ https://www.ncbi.nlm.nih.gov/pubmed/37968725 http://dx.doi.org/10.1186/s13024-023-00677-6 |
work_keys_str_mv | AT ullgrenabbe alteredplasmaproteinprofilesingeneticftdagenfistudy AT oijerstedtlinn alteredplasmaproteinprofilesingeneticftdagenfistudy AT olofssonjennie alteredplasmaproteinprofilesingeneticftdagenfistudy AT bergstromsofia alteredplasmaproteinprofilesingeneticftdagenfistudy AT remnestaljulia alteredplasmaproteinprofilesingeneticftdagenfistudy AT vanswietenjohnc alteredplasmaproteinprofilesingeneticftdagenfistudy AT jiskootlizec alteredplasmaproteinprofilesingeneticftdagenfistudy AT seelaarharro alteredplasmaproteinprofilesingeneticftdagenfistudy AT borronibarbara alteredplasmaproteinprofilesingeneticftdagenfistudy AT sanchezvalleraquel alteredplasmaproteinprofilesingeneticftdagenfistudy AT morenofermin alteredplasmaproteinprofilesingeneticftdagenfistudy AT laforcerobert alteredplasmaproteinprofilesingeneticftdagenfistudy AT synofzikmatthis alteredplasmaproteinprofilesingeneticftdagenfistudy AT galimbertidaniela alteredplasmaproteinprofilesingeneticftdagenfistudy AT rowejamesb alteredplasmaproteinprofilesingeneticftdagenfistudy AT masellismario alteredplasmaproteinprofilesingeneticftdagenfistudy AT tartagliamariacarmela alteredplasmaproteinprofilesingeneticftdagenfistudy AT fingerelizabeth alteredplasmaproteinprofilesingeneticftdagenfistudy AT vandenbergherik alteredplasmaproteinprofilesingeneticftdagenfistudy AT demendoncaalexandre alteredplasmaproteinprofilesingeneticftdagenfistudy AT tiraboschpietro alteredplasmaproteinprofilesingeneticftdagenfistudy AT santanaisabel alteredplasmaproteinprofilesingeneticftdagenfistudy AT ducharmesimon alteredplasmaproteinprofilesingeneticftdagenfistudy AT butlerchrisr alteredplasmaproteinprofilesingeneticftdagenfistudy AT gerhardalexander alteredplasmaproteinprofilesingeneticftdagenfistudy AT ottomarkus alteredplasmaproteinprofilesingeneticftdagenfistudy AT bouziguesarabella alteredplasmaproteinprofilesingeneticftdagenfistudy AT russelllucy alteredplasmaproteinprofilesingeneticftdagenfistudy AT swiftimogenj alteredplasmaproteinprofilesingeneticftdagenfistudy AT sogorbesteveaitana alteredplasmaproteinprofilesingeneticftdagenfistudy AT hellercarolin alteredplasmaproteinprofilesingeneticftdagenfistudy AT rohrerjonathand alteredplasmaproteinprofilesingeneticftdagenfistudy AT manberganna alteredplasmaproteinprofilesingeneticftdagenfistudy AT nilssonpeter alteredplasmaproteinprofilesingeneticftdagenfistudy AT graffcaroline alteredplasmaproteinprofilesingeneticftdagenfistudy AT alteredplasmaproteinprofilesingeneticftdagenfistudy |