Cargando…

The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity

African swine fever virus (ASFV) is a highly contagious and deadly virus that leads to high mortality rates in domestic swine populations. Although the envelope protein CD2v of ASFV has been implicated in immunomodulation, the molecular mechanisms underlying CD2v-mediated immunoregulation remain unc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Min, Lv, Lilei, Luo, Huaye, Cai, Hongming, Yu, Lingxue, Jiang, Yifeng, Gao, Fei, Tong, Wu, Li, Liwei, Li, Guoxin, Zhou, Yanjun, Tong, Guangzhi, Liu, Changlong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648359/ https://www.ncbi.nlm.nih.gov/pubmed/37968713 http://dx.doi.org/10.1186/s13567-023-01239-w

Ejemplares similares

Identification and Characterization of Cell Lines HepG2, Hep3B217 and SNU387 as Models for Porcine Epidemic Diarrhea Coronavirus Infection
por: Lv, Lilei, et al.
Publicado: (2022)

Long-Term Expansion of Porcine Intestinal Organoids Serves as an in vitro Model for Swine Enteric Coronavirus Infection
por: Zhang, Min, et al.
Publicado: (2022)

Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) From 1996 to 2017 in China
por: Jiang, Yifeng, et al.
Publicado: (2020)

The rPRRSV-E2 strain exhibited a low level of potential risk for virulence reversion
por: Jiang, Yifeng, et al.
Publicado: (2023)

Recombinant Bivalent Live Vectored Vaccine Against Classical Swine Fever and HP-PRRS Revealed Adequate Heterogeneous Protection Against NADC30-Like Strain
por: Li, Liwei, et al.
Publicado: (2022)

Identification of Virulence Associated Region during Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus during Attenuation In Vitro: Complex Question with Different Strain Backgrounds
por: Jiang, Yifeng, et al.
Publicado: (2021)

Label‐Free Quantitative Proteomic Analysis of Differentially Expressed Membrane Proteins of Pulmonary Alveolar Macrophages Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Its Attenuated Strain
por: Qu, Zehui, et al.
Publicado: (2017)

Expression of ASFV p17 in CHO cells and identification of one novel epitope using a monoclonal antibody
por: Li, Liwei, et al.
Publicado: (2023)

A highly efficient indirect ELISA and monoclonal antibody established against African swine fever virus pK205R
por: Li, Liwei, et al.
Publicado: (2023)

Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity
por: Yang, Shen, et al.
Publicado: (2016)

Development of a Monoclonal Antibody Against Porcine CD163 SRCR5 Domain Which Partially Blocks Infection of PRRSV
por: Zhang, Yujiao, et al.
Publicado: (2020)

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9’s Antiviral Effect via Nsp11 Endoribonuclease Activity
por: Zhang, Yujiao, et al.
Publicado: (2020)

Construction and in vitro evaluation of a recombinant live attenuated PRRSV expressing GM-CSF
por: Yu, Lingxue, et al.
Publicado: (2014)

Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus
por: Wang, Shuaiyong, et al.
Publicado: (2022)

Establishment of Replication Deficient Vesicular Stomatitis Virus for Studies of PEDV Spike-Mediated Cell Entry and Its Inhibition
por: Luo, Huaye, et al.
Publicado: (2023)

Porcine epidemic diarrhea virus strain FJzz1 infection induces type I/III IFNs production through RLRs and TLRs-mediated signaling
por: Chen, Pengfei, et al.
Publicado: (2022)

Gfi1-Mediated Repression of c-Fos, Egr-1 and Egr-2, and Inhibition of ERK1/2 Signaling Contribute to the Role of Gfi1 in Granulopoiesis
por: Zhang, Yangyang, et al.
Publicado: (2019)

Nonstructural Protein 2 Is Critical to Infection Efficiency of Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus on PAMs and Influence Virulence In Vivo
por: Chen, Jiazeng, et al.
Publicado: (2022)

Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas
por: Knudsen, Arnon Møldrup, et al.
Publicado: (2020)

The Indirect ELISA and Monoclonal Antibody against African Swine Fever Virus p17 Revealed Efficient Detection and Application Prospects
por: Li, Liwei, et al.
Publicado: (2022)

Elevated and sustained Egr1 and Egr2 expression controls NKT lineage differentiation in response to TCR signaling
por: Seiler, Michael P., et al.
Publicado: (2012)

Cellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo
por: Li, Liwei, et al.
Publicado: (2015)

Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling
por: Rockel, Jason S, et al.
Publicado: (2009)

Propofol induces MAPK/ERK cascade dependant expression of cFos and Egr-1 in rat hippocampal slices
por: Kidambi, Srivatsan, et al.
Publicado: (2010)

Co-expression of Ubiquitin gene and capsid protein gene enhances the potency of DNA immunization of PCV2 in mice
por: Fu, Fang, et al.
Publicado: (2011)

The Host Cell Transcription Factor EGR1 Is Induced by Bacteria through the EGFR–ERK1/2 Pathway
por: de Klerk, Nele, et al.
Publicado: (2017)

Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca(2+ )concentration, phosphorylation of ERK and activation of ternary complex factor
por: Rössler, Oliver G, et al.
Publicado: (2009)

NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity
por: Ingram, Kelley, et al.
Publicado: (2021)

Context-Dependent Egr1 Expression in the Avian Hippocampus
por: Grella, Stephanie L., et al.
Publicado: (2016)

EGR1 regulates oral epithelial cell responses to Candida albicans via the EGFR- ERK1/2 pathway
por: Dickenson, Ruth E., et al.
Publicado: (2023)

MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats
por: Wang, Manda, et al.
Publicado: (2023)

The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation
por: Boyle, Keith B., et al.
Publicado: (2009)

Utilizing host endogenous microRNAs to negatively regulate the replication of porcine reproductive and respiratory syndrome virus in MARC-145 cells
por: Li, Liwei, et al.
Publicado: (2018)

Experience-Dependent Egr1 Expression in the Hippocampus of Japanese Quail
por: Damphousse, Chelsey C., et al.
Publicado: (2022)

Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons
por: Li, Liwei, et al.
Publicado: (2015)

Generation of an infectious clone of HuN4-F112, an attenuated live vaccine strain of porcine reproductive and respiratory syndrome virus
por: Zhang, Shanrui, et al.
Publicado: (2011)

An Egr-1-specific DNAzyme regulates Egr-1 and proliferating cell nuclear antigen expression in rat vascular smooth muscle cells
por: ZHANG, JUNBIAO, et al.
Publicado: (2013)

Egr-1 Upregulates Siva-1 Expression and Induces Cardiac Fibroblast Apoptosis
por: Zins, Karin, et al.
Publicado: (2014)

A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro
por: Chen, Pengfei, et al.
Publicado: (2021)

ERK1/2-Egr-1 Signaling Pathway-Mediated Protective Effects of Electroacupuncture in a Mouse Model of Myocardial Ischemia-Reperfusion
por: Zhang, Juan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_0m899qqtfcu6cmucfb1ig7via3