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Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment

An increasing level of pesticide exposition is being observed as a result of the consumption of large amounts of fruits, vegetables and grain products, which are key components of the vegetarian diet. Fungicides have been classified as endocrine-disrupting compounds, but their mechanisms of action h...

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Autores principales: Jabłońska-Trypuć, Agata, Wydro, Urszula, Wołejko, Elżbieta, Makuła, Marcin, Krętowski, Rafał, Naumowicz, Monika, Sokołowska, Gabriela, Serra-Majem, Lluis, Cechowska-Pasko, Marzanna, Łozowicka, Bożena, Kaczyński, Piotr, Wiater, Józefa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648374/
https://www.ncbi.nlm.nih.gov/pubmed/37959855
http://dx.doi.org/10.3390/molecules28217437
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author Jabłońska-Trypuć, Agata
Wydro, Urszula
Wołejko, Elżbieta
Makuła, Marcin
Krętowski, Rafał
Naumowicz, Monika
Sokołowska, Gabriela
Serra-Majem, Lluis
Cechowska-Pasko, Marzanna
Łozowicka, Bożena
Kaczyński, Piotr
Wiater, Józefa
author_facet Jabłońska-Trypuć, Agata
Wydro, Urszula
Wołejko, Elżbieta
Makuła, Marcin
Krętowski, Rafał
Naumowicz, Monika
Sokołowska, Gabriela
Serra-Majem, Lluis
Cechowska-Pasko, Marzanna
Łozowicka, Bożena
Kaczyński, Piotr
Wiater, Józefa
author_sort Jabłońska-Trypuć, Agata
collection PubMed
description An increasing level of pesticide exposition is being observed as a result of the consumption of large amounts of fruits, vegetables and grain products, which are key components of the vegetarian diet. Fungicides have been classified as endocrine-disrupting compounds, but their mechanisms of action have not yet been clarified. The effect of boscalid (B), cyprodinil (C) and iprodione (I) combined with Tamoxifen (T) and 17β-estradiol (E2) on cell viability, cell proliferation, reporter gene expression, ROS content, the cell membrane’s function, cell morphology and antioxidant enzymes gene expression in MCF-7 and T47D-KBluc cell lines were investigated. The cell lines were chosen due to their response to 17β -estradiol. The selected fungicides are commonly used in Poland to protect crops against fungi. Our results revealed that the studied fungicides caused significant increases in cell viability and proliferation, and estrogenic activity was present in all studied compounds depending on their concentrations. Oxidative stress activated uncontrolled cancer cell proliferation by inducing ROS production and by inhibiting antioxidant defense. Our findings verify that the studied fungicides could possibly exhibit endocrine-disrupting properties and exposure should be avoided.
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spelling pubmed-106483742023-11-05 Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment Jabłońska-Trypuć, Agata Wydro, Urszula Wołejko, Elżbieta Makuła, Marcin Krętowski, Rafał Naumowicz, Monika Sokołowska, Gabriela Serra-Majem, Lluis Cechowska-Pasko, Marzanna Łozowicka, Bożena Kaczyński, Piotr Wiater, Józefa Molecules Article An increasing level of pesticide exposition is being observed as a result of the consumption of large amounts of fruits, vegetables and grain products, which are key components of the vegetarian diet. Fungicides have been classified as endocrine-disrupting compounds, but their mechanisms of action have not yet been clarified. The effect of boscalid (B), cyprodinil (C) and iprodione (I) combined with Tamoxifen (T) and 17β-estradiol (E2) on cell viability, cell proliferation, reporter gene expression, ROS content, the cell membrane’s function, cell morphology and antioxidant enzymes gene expression in MCF-7 and T47D-KBluc cell lines were investigated. The cell lines were chosen due to their response to 17β -estradiol. The selected fungicides are commonly used in Poland to protect crops against fungi. Our results revealed that the studied fungicides caused significant increases in cell viability and proliferation, and estrogenic activity was present in all studied compounds depending on their concentrations. Oxidative stress activated uncontrolled cancer cell proliferation by inducing ROS production and by inhibiting antioxidant defense. Our findings verify that the studied fungicides could possibly exhibit endocrine-disrupting properties and exposure should be avoided. MDPI 2023-11-05 /pmc/articles/PMC10648374/ /pubmed/37959855 http://dx.doi.org/10.3390/molecules28217437 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jabłońska-Trypuć, Agata
Wydro, Urszula
Wołejko, Elżbieta
Makuła, Marcin
Krętowski, Rafał
Naumowicz, Monika
Sokołowska, Gabriela
Serra-Majem, Lluis
Cechowska-Pasko, Marzanna
Łozowicka, Bożena
Kaczyński, Piotr
Wiater, Józefa
Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment
title Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment
title_full Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment
title_fullStr Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment
title_full_unstemmed Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment
title_short Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment
title_sort selected fungicides as potential edc estrogenic micropollutants in the environment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648374/
https://www.ncbi.nlm.nih.gov/pubmed/37959855
http://dx.doi.org/10.3390/molecules28217437
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