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Trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study

BACKGROUND: Postoperative analgesic management is an ongoing challenge. The pain threshold (PT) is an objective index that reflects the body’s sensitivity to pain and can be used for quantitative pain assessment. We hypothesized that the PT is correlated with postoperative pain and can thus be used...

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Autores principales: Wang, Fei, Ou, Meng-Chan, Zhu, Yi-Hao, Zhu, Tao, Hao, Xue-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648379/
https://www.ncbi.nlm.nih.gov/pubmed/37964267
http://dx.doi.org/10.1186/s13019-023-02424-w
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author Wang, Fei
Ou, Meng-Chan
Zhu, Yi-Hao
Zhu, Tao
Hao, Xue-Chao
author_facet Wang, Fei
Ou, Meng-Chan
Zhu, Yi-Hao
Zhu, Tao
Hao, Xue-Chao
author_sort Wang, Fei
collection PubMed
description BACKGROUND: Postoperative analgesic management is an ongoing challenge. The pain threshold (PT) is an objective index that reflects the body’s sensitivity to pain and can be used for quantitative pain assessment. We hypothesized that the PT is correlated with postoperative pain and can thus be used to guide postoperative pain management. METHODS: This study involved 93 patients who underwent thoracoscopic surgery from December 2019 to February 2020. The PT was measured with transcutaneous electrical stimulation before surgery (T(0)) and at 1 h (T(1)), 6 h (T(6)), and 24 h (T(24)) after surgery. The visual analogue scale (VAS) score was used to evaluate the severity of postoperative pain at the same time. The PT variation (PTV) after surgery was calculated as the ratio of the postoperative PT to preoperative PT. RESULTS: The postoperative PT was higher than the preoperative PT and showed a downward trend within 24 h after surgery; the PTV also showed a downward trend within 24 h after surgery. PT-T(1) was negatively correlated with VAS-T(1) at rest and during motion (rest: VAS-T(1)r = − 0.274, P = 0.008; motion: VAS-T(1)r = − 0.298, P = 0.004). PTV-T(1) was negatively correlated with VAS-T(1) during motion (r = − 0.213, P = 0.04). Lower VAS-T(1) scores (< 4) at rest and during motion were associated with higher PT-T(1) (rest: t = 2.452, P = 0.016; motion: t = 2.138, P = 0.035). The intraoperative sufentanil dose was associated with a postoperative increase in PTV-T(1). Increased rescue analgesic administration was associated with PTV elevation. However, the incidence of dizziness in patients with moderate PTV-T(24) was lower than that in patients with high or low PTV-T(24) (χ(2) = 8.297, P = 0.015). CONCLUSIONS: The postoperative PT was higher than the preoperative PT and showed a downward trend within 24 h after surgery; PTV also showed a downward trend within 24 h after surgery. The PT and PTV were negatively correlated with the pain intensity at rest and during motion and were associated with perioperative analgesic consumption and the incidence of adverse events.
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spelling pubmed-106483792023-11-14 Trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study Wang, Fei Ou, Meng-Chan Zhu, Yi-Hao Zhu, Tao Hao, Xue-Chao J Cardiothorac Surg Research BACKGROUND: Postoperative analgesic management is an ongoing challenge. The pain threshold (PT) is an objective index that reflects the body’s sensitivity to pain and can be used for quantitative pain assessment. We hypothesized that the PT is correlated with postoperative pain and can thus be used to guide postoperative pain management. METHODS: This study involved 93 patients who underwent thoracoscopic surgery from December 2019 to February 2020. The PT was measured with transcutaneous electrical stimulation before surgery (T(0)) and at 1 h (T(1)), 6 h (T(6)), and 24 h (T(24)) after surgery. The visual analogue scale (VAS) score was used to evaluate the severity of postoperative pain at the same time. The PT variation (PTV) after surgery was calculated as the ratio of the postoperative PT to preoperative PT. RESULTS: The postoperative PT was higher than the preoperative PT and showed a downward trend within 24 h after surgery; the PTV also showed a downward trend within 24 h after surgery. PT-T(1) was negatively correlated with VAS-T(1) at rest and during motion (rest: VAS-T(1)r = − 0.274, P = 0.008; motion: VAS-T(1)r = − 0.298, P = 0.004). PTV-T(1) was negatively correlated with VAS-T(1) during motion (r = − 0.213, P = 0.04). Lower VAS-T(1) scores (< 4) at rest and during motion were associated with higher PT-T(1) (rest: t = 2.452, P = 0.016; motion: t = 2.138, P = 0.035). The intraoperative sufentanil dose was associated with a postoperative increase in PTV-T(1). Increased rescue analgesic administration was associated with PTV elevation. However, the incidence of dizziness in patients with moderate PTV-T(24) was lower than that in patients with high or low PTV-T(24) (χ(2) = 8.297, P = 0.015). CONCLUSIONS: The postoperative PT was higher than the preoperative PT and showed a downward trend within 24 h after surgery; PTV also showed a downward trend within 24 h after surgery. The PT and PTV were negatively correlated with the pain intensity at rest and during motion and were associated with perioperative analgesic consumption and the incidence of adverse events. BioMed Central 2023-11-14 /pmc/articles/PMC10648379/ /pubmed/37964267 http://dx.doi.org/10.1186/s13019-023-02424-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Fei
Ou, Meng-Chan
Zhu, Yi-Hao
Zhu, Tao
Hao, Xue-Chao
Trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study
title Trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study
title_full Trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study
title_fullStr Trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study
title_full_unstemmed Trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study
title_short Trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study
title_sort trajectory of pain threshold and its association with acute pain after thoracic surgery: a prospective observational study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648379/
https://www.ncbi.nlm.nih.gov/pubmed/37964267
http://dx.doi.org/10.1186/s13019-023-02424-w
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