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Label-Free Imaging of Solid-Phase Peptide Synthesis Products and Their Modifications Tethered in Microspots Using Time-of-Flight Secondary Ion Mass Spectrometry

Time-of-flight secondary ion mass spectrometry is used to analyze solid-phase synthesis products in 60 µm spots of high-density peptide arrays. As a result, a table of specific fragments for the individual detection of amino acids and their side chain protecting groups within peptides is compiled. T...

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Detalles Bibliográficos
Autores principales: Schmidt, Dimitry, Maier, Josef, Bernauer, Hubert, Nesterov-Mueller, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648460/
https://www.ncbi.nlm.nih.gov/pubmed/37958928
http://dx.doi.org/10.3390/ijms242115945