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Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer–Koch Modeling
Accurately printing customizable scaffolds is a challenging task because of the complexity of bone tissue composition, organization, and mechanical behavior. Graphene oxide (GO) and poly-L-lactic acid (PLLA) have drawn attention in the field of bone regeneration. However, as far as we know, the Fisc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648465/ https://www.ncbi.nlm.nih.gov/pubmed/37959893 http://dx.doi.org/10.3390/polym15214213 |
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author | da Silva, Thamires Santos Horvath-Pereira, Bianca de Oliveira da Silva-Júnior, Leandro Norberto Tenório Fireman, João Víctor Barbosa Mattar, Michel Félix, Marcílio Buchaim, Rogerio Leone Carreira, Ana Claudia Oliveira Miglino, Maria Angelica Soares, Marcelo Melo |
author_facet | da Silva, Thamires Santos Horvath-Pereira, Bianca de Oliveira da Silva-Júnior, Leandro Norberto Tenório Fireman, João Víctor Barbosa Mattar, Michel Félix, Marcílio Buchaim, Rogerio Leone Carreira, Ana Claudia Oliveira Miglino, Maria Angelica Soares, Marcelo Melo |
author_sort | da Silva, Thamires Santos |
collection | PubMed |
description | Accurately printing customizable scaffolds is a challenging task because of the complexity of bone tissue composition, organization, and mechanical behavior. Graphene oxide (GO) and poly-L-lactic acid (PLLA) have drawn attention in the field of bone regeneration. However, as far as we know, the Fischer–Koch model of the GO/PLLA association for three-dimensional (3D) printing was not previously reported. This study characterizes the properties of GO/PLLA-printed scaffolds in order to achieve reproducibility of the trabecula, from virtual planning to the printed piece, as well as its response to a cell viability assay. Fourier-transform infrared and Raman spectroscopy were performed to evaluate the physicochemical properties of the nanocomposites. Cellular adhesion, proliferation, and growth on the nanocomposites were evaluated using scanning electron microscopy. Cell viability tests revealed no significant differences among different trabeculae and cell types, indicating that these nanocomposites were not cytotoxic. The Fischer Koch modeling yielded satisfactory results and can thus be used in studies directed at diverse medical applications, including bone tissue engineering and implants. |
format | Online Article Text |
id | pubmed-10648465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106484652023-10-25 Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer–Koch Modeling da Silva, Thamires Santos Horvath-Pereira, Bianca de Oliveira da Silva-Júnior, Leandro Norberto Tenório Fireman, João Víctor Barbosa Mattar, Michel Félix, Marcílio Buchaim, Rogerio Leone Carreira, Ana Claudia Oliveira Miglino, Maria Angelica Soares, Marcelo Melo Polymers (Basel) Article Accurately printing customizable scaffolds is a challenging task because of the complexity of bone tissue composition, organization, and mechanical behavior. Graphene oxide (GO) and poly-L-lactic acid (PLLA) have drawn attention in the field of bone regeneration. However, as far as we know, the Fischer–Koch model of the GO/PLLA association for three-dimensional (3D) printing was not previously reported. This study characterizes the properties of GO/PLLA-printed scaffolds in order to achieve reproducibility of the trabecula, from virtual planning to the printed piece, as well as its response to a cell viability assay. Fourier-transform infrared and Raman spectroscopy were performed to evaluate the physicochemical properties of the nanocomposites. Cellular adhesion, proliferation, and growth on the nanocomposites were evaluated using scanning electron microscopy. Cell viability tests revealed no significant differences among different trabeculae and cell types, indicating that these nanocomposites were not cytotoxic. The Fischer Koch modeling yielded satisfactory results and can thus be used in studies directed at diverse medical applications, including bone tissue engineering and implants. MDPI 2023-10-25 /pmc/articles/PMC10648465/ /pubmed/37959893 http://dx.doi.org/10.3390/polym15214213 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article da Silva, Thamires Santos Horvath-Pereira, Bianca de Oliveira da Silva-Júnior, Leandro Norberto Tenório Fireman, João Víctor Barbosa Mattar, Michel Félix, Marcílio Buchaim, Rogerio Leone Carreira, Ana Claudia Oliveira Miglino, Maria Angelica Soares, Marcelo Melo Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer–Koch Modeling |
title | Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer–Koch Modeling |
title_full | Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer–Koch Modeling |
title_fullStr | Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer–Koch Modeling |
title_full_unstemmed | Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer–Koch Modeling |
title_short | Three-Dimensional Printing of Graphene Oxide/Poly-L-Lactic Acid Scaffolds Using Fischer–Koch Modeling |
title_sort | three-dimensional printing of graphene oxide/poly-l-lactic acid scaffolds using fischer–koch modeling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648465/ https://www.ncbi.nlm.nih.gov/pubmed/37959893 http://dx.doi.org/10.3390/polym15214213 |
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