A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor

An iodine-mediated one-pot synthesis of pyrrolo/indolo [1,2-a]quinoxalines and quinazolin-4-one via utilizing epoxides as alkyl precursors under metal-free conditions has been described. Both 1-(2-aminophenyl)-pyrrole and 2-aminobenzamide could be applied to this protocol. A total of 33 desired prod...

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Detalles Bibliográficos
Autores principales: Lv, Xueyan, Lv, Lili, Li, Shichen, Ding, Chengcheng, Yang, Bingchuan, Ma, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648482/
https://www.ncbi.nlm.nih.gov/pubmed/37959810
http://dx.doi.org/10.3390/molecules28217391
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author Lv, Xueyan
Lv, Lili
Li, Shichen
Ding, Chengcheng
Yang, Bingchuan
Ma, Chen
author_facet Lv, Xueyan
Lv, Lili
Li, Shichen
Ding, Chengcheng
Yang, Bingchuan
Ma, Chen
author_sort Lv, Xueyan
collection PubMed
description An iodine-mediated one-pot synthesis of pyrrolo/indolo [1,2-a]quinoxalines and quinazolin-4-one via utilizing epoxides as alkyl precursors under metal-free conditions has been described. Both 1-(2-aminophenyl)-pyrrole and 2-aminobenzamide could be applied to this protocol. A total of 33 desired products were obtained with moderate to good yields. This methodology was suitable for wide-scale preparation and the obtained products could be further modified into promising pharmaceutically active reagents.
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spelling pubmed-106484822023-11-02 A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor Lv, Xueyan Lv, Lili Li, Shichen Ding, Chengcheng Yang, Bingchuan Ma, Chen Molecules Article An iodine-mediated one-pot synthesis of pyrrolo/indolo [1,2-a]quinoxalines and quinazolin-4-one via utilizing epoxides as alkyl precursors under metal-free conditions has been described. Both 1-(2-aminophenyl)-pyrrole and 2-aminobenzamide could be applied to this protocol. A total of 33 desired products were obtained with moderate to good yields. This methodology was suitable for wide-scale preparation and the obtained products could be further modified into promising pharmaceutically active reagents. MDPI 2023-11-02 /pmc/articles/PMC10648482/ /pubmed/37959810 http://dx.doi.org/10.3390/molecules28217391 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lv, Xueyan
Lv, Lili
Li, Shichen
Ding, Chengcheng
Yang, Bingchuan
Ma, Chen
A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor
title A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor
title_full A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor
title_fullStr A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor
title_full_unstemmed A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor
title_short A Direct Method for Synthesis of Quinoxalines and Quinazolinones Using Epoxides as Alkyl Precursor
title_sort direct method for synthesis of quinoxalines and quinazolinones using epoxides as alkyl precursor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648482/
https://www.ncbi.nlm.nih.gov/pubmed/37959810
http://dx.doi.org/10.3390/molecules28217391
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