PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

The gene encoding the transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) was targeted in mice. PGC-1α null (PGC-1α(−/−)) mice were viable. However, extensive phenotyping revealed multi-system abnormalities indicative of an abnormal energy metabolic pheno...

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Detalles Bibliográficos
Autores principales: Leone, Teresa C, Lehman, John J, Finck, Brian N, Schaeffer, Paul J, Wende, Adam R, Boudina, Sihem, Courtois, Michael, Wozniak, David F, Sambandam, Nandakumar, Bernal-Mizrachi, Carlos, Chen, Zhouji, O. Holloszy, John, Medeiros, Denis M, Schmidt, Robert E, Saffitz, Jeffrey E, Abel, E. Dale, Semenkovich, Clay F, Kelly, Daniel P
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064854/
https://www.ncbi.nlm.nih.gov/pubmed/15760270
http://dx.doi.org/10.1371/journal.pbio.0030101

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