Design, Synthesis, and Antiproliferative Activity of Selective Histone Deacetylases 6 Inhibitors Containing a Tetrahydropyridopyrimidine Scaffold

The development of selective histone deacetylase 6 inhibitors (sHDAC6is) is being recognized as a therapeutic approach for cancers. In this paper, we designed a series of novel tetrahydropyridopyrimidine derivatives as sHDAC6 inhibitors. The most potent compound, 8-(2, 4-bis(3-methoxyphenyl)-5, 8-di...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Liu, Youcai, Zhang, Lejing, Wang, Yajuan, Li, Zhaoxi, Chen, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648541/
https://www.ncbi.nlm.nih.gov/pubmed/37959743
http://dx.doi.org/10.3390/molecules28217323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648541/
https://www.ncbi.nlm.nih.gov/pubmed/37959743
http://dx.doi.org/10.3390/molecules28217323

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