Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma

The malignant Hodgkin and Reed Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) are scarce in affected lymph nodes, creating a challenge to detect driver somatic mutations. As an alternative to cell purification techniques, we hypothesized that ultra-deep exome sequencing would allow genomi...

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Detalles Bibliográficos
Autores principales: Gomez, Felicia, Fisk, Bryan, McMichael, Joshua F., Mosior, Matthew, Foltz, Jennifer A., Skidmore, Zachary L., Duncavage, Eric J., Miller, Christopher A., Abel, Haley, Li, Yi-Shan, Russler-Germain, David A., Krysiak, Kilannin, Watkins, Marcus P., Ramirez, Cody A., Schmidt, Alina, Martins Rodrigues, Fernanda, Trani, Lee, Khanna, Ajay, Wagner, Julia A., Fulton, Robert S., Fronick, Catrina C., O'Laughlin, Michelle D., Schappe, Timothy, Cashen, Amanda F., Mehta-Shah, Neha, Kahl, Brad S., Walker, Jason, Bartlett, Nancy L., Griffith, Malachi, Fehniger, Todd A., Griffith, Obi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648575/
https://www.ncbi.nlm.nih.gov/pubmed/37910143
http://dx.doi.org/10.1158/2767-9764.CRC-23-0140

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