Cargando…
The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions
The incidence of type 2 diabetes is increasing every year and has become a serious public health problem. In addition to genetic factors, environmental factors in early life development are risk factors for diabetes. There is growing evidence that the gut microbiota plays an important role in glucos...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648599/ https://www.ncbi.nlm.nih.gov/pubmed/37960204 http://dx.doi.org/10.3390/nu15214551 |
_version_ | 1785135375723790336 |
---|---|
author | Ren, Yaolin Zeng, Yuan Wu, Yifan Yu, Jie Zhang, Qian Xiao, Xinhua |
author_facet | Ren, Yaolin Zeng, Yuan Wu, Yifan Yu, Jie Zhang, Qian Xiao, Xinhua |
author_sort | Ren, Yaolin |
collection | PubMed |
description | The incidence of type 2 diabetes is increasing every year and has become a serious public health problem. In addition to genetic factors, environmental factors in early life development are risk factors for diabetes. There is growing evidence that the gut microbiota plays an important role in glucose metabolism, and the gut microbiota of pregnant women with gestational diabetes mellitus (GDM) differs significantly from that of healthy pregnant women. This article reviews the role of maternal gut microbiota in offspring glucose metabolism. To explore the potential mechanisms by which the gut microbiota affects glucose metabolism in offspring, we summarize clinical studies and experimental animal models that support the hypothesis that the gut microbiota affects glucose metabolism in offspring from dams with GDM and discuss interventions that could improve glucose metabolism in offspring. Given that adverse pregnancy outcomes severely impact the quality of survival, reversing the deleterious effects of abnormal glucose metabolism in offspring through early intervention is important for both mothers and their offspring. |
format | Online Article Text |
id | pubmed-10648599 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106485992023-10-27 The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions Ren, Yaolin Zeng, Yuan Wu, Yifan Yu, Jie Zhang, Qian Xiao, Xinhua Nutrients Review The incidence of type 2 diabetes is increasing every year and has become a serious public health problem. In addition to genetic factors, environmental factors in early life development are risk factors for diabetes. There is growing evidence that the gut microbiota plays an important role in glucose metabolism, and the gut microbiota of pregnant women with gestational diabetes mellitus (GDM) differs significantly from that of healthy pregnant women. This article reviews the role of maternal gut microbiota in offspring glucose metabolism. To explore the potential mechanisms by which the gut microbiota affects glucose metabolism in offspring, we summarize clinical studies and experimental animal models that support the hypothesis that the gut microbiota affects glucose metabolism in offspring from dams with GDM and discuss interventions that could improve glucose metabolism in offspring. Given that adverse pregnancy outcomes severely impact the quality of survival, reversing the deleterious effects of abnormal glucose metabolism in offspring through early intervention is important for both mothers and their offspring. MDPI 2023-10-27 /pmc/articles/PMC10648599/ /pubmed/37960204 http://dx.doi.org/10.3390/nu15214551 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ren, Yaolin Zeng, Yuan Wu, Yifan Yu, Jie Zhang, Qian Xiao, Xinhua The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions |
title | The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions |
title_full | The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions |
title_fullStr | The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions |
title_full_unstemmed | The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions |
title_short | The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions |
title_sort | role of gut microbiota in gestational diabetes mellitus affecting intergenerational glucose metabolism: possible mechanisms and interventions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648599/ https://www.ncbi.nlm.nih.gov/pubmed/37960204 http://dx.doi.org/10.3390/nu15214551 |
work_keys_str_mv | AT renyaolin theroleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT zengyuan theroleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT wuyifan theroleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT yujie theroleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT zhangqian theroleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT xiaoxinhua theroleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT renyaolin roleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT zengyuan roleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT wuyifan roleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT yujie roleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT zhangqian roleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions AT xiaoxinhua roleofgutmicrobiotaingestationaldiabetesmellitusaffectingintergenerationalglucosemetabolismpossiblemechanismsandinterventions |