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The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions

The incidence of type 2 diabetes is increasing every year and has become a serious public health problem. In addition to genetic factors, environmental factors in early life development are risk factors for diabetes. There is growing evidence that the gut microbiota plays an important role in glucos...

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Detalles Bibliográficos
Autores principales: Ren, Yaolin, Zeng, Yuan, Wu, Yifan, Yu, Jie, Zhang, Qian, Xiao, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648599/
https://www.ncbi.nlm.nih.gov/pubmed/37960204
http://dx.doi.org/10.3390/nu15214551
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author Ren, Yaolin
Zeng, Yuan
Wu, Yifan
Yu, Jie
Zhang, Qian
Xiao, Xinhua
author_facet Ren, Yaolin
Zeng, Yuan
Wu, Yifan
Yu, Jie
Zhang, Qian
Xiao, Xinhua
author_sort Ren, Yaolin
collection PubMed
description The incidence of type 2 diabetes is increasing every year and has become a serious public health problem. In addition to genetic factors, environmental factors in early life development are risk factors for diabetes. There is growing evidence that the gut microbiota plays an important role in glucose metabolism, and the gut microbiota of pregnant women with gestational diabetes mellitus (GDM) differs significantly from that of healthy pregnant women. This article reviews the role of maternal gut microbiota in offspring glucose metabolism. To explore the potential mechanisms by which the gut microbiota affects glucose metabolism in offspring, we summarize clinical studies and experimental animal models that support the hypothesis that the gut microbiota affects glucose metabolism in offspring from dams with GDM and discuss interventions that could improve glucose metabolism in offspring. Given that adverse pregnancy outcomes severely impact the quality of survival, reversing the deleterious effects of abnormal glucose metabolism in offspring through early intervention is important for both mothers and their offspring.
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spelling pubmed-106485992023-10-27 The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions Ren, Yaolin Zeng, Yuan Wu, Yifan Yu, Jie Zhang, Qian Xiao, Xinhua Nutrients Review The incidence of type 2 diabetes is increasing every year and has become a serious public health problem. In addition to genetic factors, environmental factors in early life development are risk factors for diabetes. There is growing evidence that the gut microbiota plays an important role in glucose metabolism, and the gut microbiota of pregnant women with gestational diabetes mellitus (GDM) differs significantly from that of healthy pregnant women. This article reviews the role of maternal gut microbiota in offspring glucose metabolism. To explore the potential mechanisms by which the gut microbiota affects glucose metabolism in offspring, we summarize clinical studies and experimental animal models that support the hypothesis that the gut microbiota affects glucose metabolism in offspring from dams with GDM and discuss interventions that could improve glucose metabolism in offspring. Given that adverse pregnancy outcomes severely impact the quality of survival, reversing the deleterious effects of abnormal glucose metabolism in offspring through early intervention is important for both mothers and their offspring. MDPI 2023-10-27 /pmc/articles/PMC10648599/ /pubmed/37960204 http://dx.doi.org/10.3390/nu15214551 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ren, Yaolin
Zeng, Yuan
Wu, Yifan
Yu, Jie
Zhang, Qian
Xiao, Xinhua
The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions
title The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions
title_full The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions
title_fullStr The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions
title_full_unstemmed The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions
title_short The Role of Gut Microbiota in Gestational Diabetes Mellitus Affecting Intergenerational Glucose Metabolism: Possible Mechanisms and Interventions
title_sort role of gut microbiota in gestational diabetes mellitus affecting intergenerational glucose metabolism: possible mechanisms and interventions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648599/
https://www.ncbi.nlm.nih.gov/pubmed/37960204
http://dx.doi.org/10.3390/nu15214551
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