The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling

BACKGROUND: Breast cancer stem cells (BCSCs) are resistant to standard therapies, facilitate tumor dissemination, and contribute to relapse and progression. Super-enhancers are regulators of stemness, and BET proteins, which are critical for super-enhancer function, are a potential therapeutic targe...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharma, Deeksha, Hager, Cody G., Shang, Li, Tran, Lam, Zhu, Yongyou, Ma, Aihui, Magnuson, Brian, Lesko, Matthew W., Wicha, Max S., Burness, Monika L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648675/
https://www.ncbi.nlm.nih.gov/pubmed/37968653
http://dx.doi.org/10.1186/s13058-023-01715-3

Ejemplares similares

Ejemplares similares