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Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products
Pancreatic ductal adenocarcinoma (PDAC), a highly malignant neoplasm, is classified as one of the most severe and devastating types of cancer. PDAC is a notable malignancy that exhibits a discouraging prognosis and a rising occurrence. The interplay between diabetes and pancreatic cancer exhibits a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648679/ https://www.ncbi.nlm.nih.gov/pubmed/37958889 http://dx.doi.org/10.3390/ijms242115906 |
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author | Park, Moon Nyeo |
author_facet | Park, Moon Nyeo |
author_sort | Park, Moon Nyeo |
collection | PubMed |
description | Pancreatic ductal adenocarcinoma (PDAC), a highly malignant neoplasm, is classified as one of the most severe and devastating types of cancer. PDAC is a notable malignancy that exhibits a discouraging prognosis and a rising occurrence. The interplay between diabetes and pancreatic cancer exhibits a reciprocal causation. The identified metabolic disorder has been observed to possess noteworthy consequences on health outcomes, resulting in elevated rates of morbidity. The principal mechanisms involve the suppression of the immune system, the activation of pancreatic stellate cells (PSCs), and the onset of systemic metabolic disease caused by dysfunction of the islets. From this point forward, it is important to recognize that pancreatic-cancer-related diabetes (PCRD) has the ability to increase the likelihood of developing pancreatic cancer. This highlights the complex relationship that exists between these two physiological states. Therefore, we investigated into the complex domain of PSCs, elucidating their intricate signaling pathways and the profound influence of chemokines on their behavior and final outcome. In order to surmount the obstacle of drug resistance and eliminate PDAC, researchers have undertaken extensive efforts to explore and cultivate novel natural compounds of the next generation. Additional investigation is necessary in order to comprehensively comprehend the effect of PCRD-mediated apoptosis on the progression and onset of PDAC through the utilization of natural compounds. This study aims to examine the potential anticancer properties of natural compounds in individuals with diabetes who are undergoing chemotherapy, targeted therapy, or immunotherapy. It is anticipated that these compounds will exhibit increased potency and possess enhanced pharmacological benefits. According to our research findings, it is indicated that naturally derived chemical compounds hold potential in the development of PDAC therapies that are both safe and efficacious. |
format | Online Article Text |
id | pubmed-10648679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106486792023-11-02 Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products Park, Moon Nyeo Int J Mol Sci Review Pancreatic ductal adenocarcinoma (PDAC), a highly malignant neoplasm, is classified as one of the most severe and devastating types of cancer. PDAC is a notable malignancy that exhibits a discouraging prognosis and a rising occurrence. The interplay between diabetes and pancreatic cancer exhibits a reciprocal causation. The identified metabolic disorder has been observed to possess noteworthy consequences on health outcomes, resulting in elevated rates of morbidity. The principal mechanisms involve the suppression of the immune system, the activation of pancreatic stellate cells (PSCs), and the onset of systemic metabolic disease caused by dysfunction of the islets. From this point forward, it is important to recognize that pancreatic-cancer-related diabetes (PCRD) has the ability to increase the likelihood of developing pancreatic cancer. This highlights the complex relationship that exists between these two physiological states. Therefore, we investigated into the complex domain of PSCs, elucidating their intricate signaling pathways and the profound influence of chemokines on their behavior and final outcome. In order to surmount the obstacle of drug resistance and eliminate PDAC, researchers have undertaken extensive efforts to explore and cultivate novel natural compounds of the next generation. Additional investigation is necessary in order to comprehensively comprehend the effect of PCRD-mediated apoptosis on the progression and onset of PDAC through the utilization of natural compounds. This study aims to examine the potential anticancer properties of natural compounds in individuals with diabetes who are undergoing chemotherapy, targeted therapy, or immunotherapy. It is anticipated that these compounds will exhibit increased potency and possess enhanced pharmacological benefits. According to our research findings, it is indicated that naturally derived chemical compounds hold potential in the development of PDAC therapies that are both safe and efficacious. MDPI 2023-11-02 /pmc/articles/PMC10648679/ /pubmed/37958889 http://dx.doi.org/10.3390/ijms242115906 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Park, Moon Nyeo Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products |
title | Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products |
title_full | Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products |
title_fullStr | Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products |
title_full_unstemmed | Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products |
title_short | Therapeutic Strategies for Pancreatic-Cancer-Related Type 2 Diabetes Centered around Natural Products |
title_sort | therapeutic strategies for pancreatic-cancer-related type 2 diabetes centered around natural products |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648679/ https://www.ncbi.nlm.nih.gov/pubmed/37958889 http://dx.doi.org/10.3390/ijms242115906 |
work_keys_str_mv | AT parkmoonnyeo therapeuticstrategiesforpancreaticcancerrelatedtype2diabetescenteredaroundnaturalproducts |