Cargando…

Prenatal Cannabinoid Exposure Elicits Memory Deficits Associated with Reduced PSA-NCAM Expression, Altered Glutamatergic Signaling, and Adaptations in Hippocampal Synaptic Plasticity

Cannabis is now one of the most commonly used illicit substances among pregnant women. This is particularly concerning since developmental exposure to cannabinoids can elicit enduring neurofunctional and cognitive alterations. This study investigates the mechanisms of learning and memory deficits re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pinky, Priyanka D., Bloemer, Jenna, Smith, Warren D., Du, Yifeng, Heslin, Ryan T., Setti, Sharay E., Pfitzer, Jeremiah C., Chowdhury, Kawsar, Hong, Hao, Bhattacharya, Subhrajit, Dhanasekaran, Muralikrishnan, Dityatev, Alexander, Reed, Miranda N., Suppiramaniam, Vishnu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648717/ https://www.ncbi.nlm.nih.gov/pubmed/37947603 http://dx.doi.org/10.3390/cells12212525

Ejemplares similares

Effects of prenatal synthetic cannabinoid exposure on the cerebellum of adolescent rat offspring
por: Pinky, Priyanka D., et al.
Publicado: (2021)

Neuronal CXCL10/CXCR3 Axis Mediates the Induction of Cerebral Hyperexcitability by Peripheral Viral Challenge
por: Petrisko, Tiffany J., et al.
Publicado: (2020)

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress
por: Govindarajulu, Manoj, et al.
Publicado: (2020)

Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity
por: Bhattacharya, Dwipayan, et al.
Publicado: (2020)

Role of Adiponectin in Central Nervous System Disorders
por: Bloemer, Jenna, et al.
Publicado: (2018)

Differential Effects of Human P301L Tau Expression in Young versus Aged Mice
por: Hunsberger, Holly C., et al.
Publicado: (2021)

Doxorubicin induces dysregulation of AMPA receptor and impairs hippocampal synaptic plasticity leading to learning and memory deficits
por: Alhowail, Ahmad H., et al.
Publicado: (2021)

Phenyl-2-aminoethyl selenide ameliorates hippocampal long-term potentiation and cognitive deficits following doxorubicin treatment
por: Alhowail, Ahmad H., et al.
Publicado: (2023)

Adiponectin Knockout Mice Display Cognitive and Synaptic Deficits
por: Bloemer, Jenna, et al.
Publicado: (2019)

Selective Cholinergic Depletion in Medial Septum Leads to Impaired Long Term Potentiation and Glutamatergic Synaptic Currents in the Hippocampus
por: Kanju, Patrick M., et al.
Publicado: (2012)

Signaling Mechanisms of Selective PPARγ Modulators in Alzheimer's Disease
por: Govindarajulu, Manoj, et al.
Publicado: (2018)

Distinctive PSA-NCAM and NCAM Hallmarks in Glutamate-Induced Dendritic Atrophy and Synaptic Disassembly
por: Podestá, María Fernanda, et al.
Publicado: (2014)

Autotaxin–Lysophosphatidic Acid Signaling in Alzheimer’s Disease
por: Ramesh, Sindhu, et al.
Publicado: (2018)

Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior
por: Barker, Jacqueline M., et al.
Publicado: (2012)

Mouse Brain PSA-NCAM Levels Are Altered by Graded-Controlled Cortical Impact Injury
por: Budinich, Craig S., et al.
Publicado: (2012)

Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis
por: Niethammer, Philipp, et al.
Publicado: (2002)

Selective PPAR-Delta/PPAR-Gamma Activation Improves Cognition in a Model of Alzheimer’s Disease
por: Steinke, Ian, et al.
Publicado: (2023)

Exploring Functional β-Cell Heterogeneity In Vivo Using PSA-NCAM as a Specific Marker
por: Karaca, Melis, et al.
Publicado: (2009)

The Neural Plasticity Theory of Depression: Assessing the Roles of Adult Neurogenesis and PSA-NCAM within the Hippocampus
por: Wainwright, Steven R., et al.
Publicado: (2013)

PSA-NCAM is Expressed in Immature, but not Recently Generated, Neurons in the Adult Cat Cerebral Cortex Layer II
por: Varea, Emilio, et al.
Publicado: (2011)

The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats
por: Rajabzadeh, Aliakbar, et al.
Publicado: (2012)

Effects of PSA Removal from NCAM on the Critical Period Plasticity Triggered by the Antidepressant Fluoxetine in the Visual Cortex
por: Guirado, Ramon, et al.
Publicado: (2016)

Chronic Stress Modulates Interneuronal Plasticity: Effects on PSA-NCAM and Perineuronal Nets in Cortical and Extracortical Regions
por: Pesarico, Ana Paula, et al.
Publicado: (2019)

The PSA-NCAM-Positive “Immature” Neurons: An Old Discovery Providing New Vistas on Brain Structural Plasticity
por: Bonfanti, Luca, et al.
Publicado: (2021)

Polysialylated-neural cell adhesion molecule (PSA-NCAM) in the human trigeminal ganglion and brainstem at prenatal and adult ages
por: Quartu, Marina, et al.
Publicado: (2008)

Promotion of Cell Migration by Neural Cell Adhesion Molecule (NCAM) Is Enhanced by PSA in a Polysialyltransferase-Specific Manner
por: Guan, Feng, et al.
Publicado: (2015)

Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat Model
por: Bhattacharya, D., et al.
Publicado: (2015)

Highly Pure and Expandable PSA-NCAM-Positive Neural Precursors from Human ESC and iPSC-Derived Neural Rosettes
por: Kim, Dae-Sung, et al.
Publicado: (2012)

PSA-NCAM positive neural progenitors stably expressing BDNF promote functional recovery in a mouse model of spinal cord injury
por: Butenschön, Jennifer, et al.
Publicado: (2016)

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway
por: Ramesh, Sindhu, et al.
Publicado: (2018)

A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats
por: Rendeiro, Catarina, et al.
Publicado: (2014)

PSA-NCAM-Negative Neural Crest Cells Emerging during Neural Induction of Pluripotent Stem Cells Cause Mesodermal Tumors and Unwanted Grafts
por: Lee, Dongjin R., et al.
Publicado: (2015)

rTg(Tau(P301L))4510 mice exhibit increased VGlut1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular glutamate release
por: Taipala, Erika, et al.
Publicado: (2022)

Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines
por: Amoureux, Marie-Claude, et al.
Publicado: (2010)

Resveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion
por: Serra, Maria Pina, et al.
Publicado: (2019)

The role of APOE4 in Alzheimer’s disease: strategies for future therapeutic interventions
por: Hunsberger, Holly C., et al.
Publicado: (2019)

Effect of Acute Stress on the Expression of BDNF, trkB, and PSA-NCAM in the Hippocampus of the Roman Rats: A Genetic Model of Vulnerability/Resistance to Stress-Induced Depression
por: Serra, Maria Pina, et al.
Publicado: (2018)

Binding properties of detergent-solubilized NCAM
Publicado: (1990)

Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission
por: Haller, J, et al.
Publicado: (2007)

Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
por: Watzlawik, Jens O., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_00v4rku6gkcjmadjisg3mi4tll