A truncated HIV Tat demonstrates potent and specific latency reversal activity

A major barrier to HIV-1 cure is caused by the pool of latently infected CD4 T-cells that persist under combination antiretroviral therapy (cART). This latent reservoir is capable of producing replication-competent infectious viruses once prolonged suppressive cART is withdrawn. Inducing the reactiv...

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Detalles Bibliográficos
Autores principales: Van Gulck, Ellen, Pardons, Marion, Nijs, Erik, Verheyen, Nick, Dockx, Koen, Van Den Eynde, Christel, Battivelli, Emilie, Vega, Jerel, Florence, Eric, Autran, Brigitte, Archin, Nancie M., Margolis, David M., Katlama, Christine, Hamimi, Chiraz, Van Den Wyngaert, Ilse, Eyassu, Filmon, Vandekerckhove, Linos, Boden, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649039/
https://www.ncbi.nlm.nih.gov/pubmed/37874295
http://dx.doi.org/10.1128/aac.00417-23

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