Evaluation of in vitro antiviral activity of SARS-CoV-2 M(pro) inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions

The unprecedented scale of the COVID-19 pandemic and the rapid evolution of SARS-CoV-2 variants underscore the need for broadly active inhibitors with a high barrier to resistance. The coronavirus main protease (M(pro)) is an essential cysteine protease required for viral polyprotein processing and...

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Detalles Bibliográficos
Autores principales: Tong, Xiao, Keung, Walter, Arnold, Lee D., Stevens, Laura J., Pruijssers, Andrea J., Kook, Seunghyi, Lopatin, Uri, Denison, Mark, Kwong, Ann D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649086/
https://www.ncbi.nlm.nih.gov/pubmed/37800975
http://dx.doi.org/10.1128/aac.00840-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649086/
https://www.ncbi.nlm.nih.gov/pubmed/37800975
http://dx.doi.org/10.1128/aac.00840-23

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