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Potential Retinal Biomarkers in Alzheimer’s Disease
Alzheimer’s disease (AD) represents a major diagnostic challenge, as early detection is crucial for effective intervention. This review examines the diagnostic challenges facing current AD evaluations and explores the emerging field of retinal alterations as early indicators. Recognizing the potenti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649108/ https://www.ncbi.nlm.nih.gov/pubmed/37958816 http://dx.doi.org/10.3390/ijms242115834 |
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author | García-Bermúdez, Mariana Yolotzin Vohra, Rupali Freude, Kristine van Wijngaarden, Peter Martin, Keith Thomsen, Maj Schneider Aldana, Blanca Irene Kolko, Miriam |
author_facet | García-Bermúdez, Mariana Yolotzin Vohra, Rupali Freude, Kristine van Wijngaarden, Peter Martin, Keith Thomsen, Maj Schneider Aldana, Blanca Irene Kolko, Miriam |
author_sort | García-Bermúdez, Mariana Yolotzin |
collection | PubMed |
description | Alzheimer’s disease (AD) represents a major diagnostic challenge, as early detection is crucial for effective intervention. This review examines the diagnostic challenges facing current AD evaluations and explores the emerging field of retinal alterations as early indicators. Recognizing the potential of the retina as a noninvasive window to the brain, we emphasize the importance of identifying retinal biomarkers in the early stages of AD. However, the examination of AD is not without its challenges, as the similarities shared with other retinal diseases introduce complexity in the search for AD-specific markers. In this review, we address the relevance of using the retina for the early diagnosis of AD and the complex challenges associated with the search for AD-specific retinal biomarkers. We provide a comprehensive overview of the current landscape and highlight avenues for progress in AD diagnosis by retinal examination. |
format | Online Article Text |
id | pubmed-10649108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106491082023-10-31 Potential Retinal Biomarkers in Alzheimer’s Disease García-Bermúdez, Mariana Yolotzin Vohra, Rupali Freude, Kristine van Wijngaarden, Peter Martin, Keith Thomsen, Maj Schneider Aldana, Blanca Irene Kolko, Miriam Int J Mol Sci Review Alzheimer’s disease (AD) represents a major diagnostic challenge, as early detection is crucial for effective intervention. This review examines the diagnostic challenges facing current AD evaluations and explores the emerging field of retinal alterations as early indicators. Recognizing the potential of the retina as a noninvasive window to the brain, we emphasize the importance of identifying retinal biomarkers in the early stages of AD. However, the examination of AD is not without its challenges, as the similarities shared with other retinal diseases introduce complexity in the search for AD-specific markers. In this review, we address the relevance of using the retina for the early diagnosis of AD and the complex challenges associated with the search for AD-specific retinal biomarkers. We provide a comprehensive overview of the current landscape and highlight avenues for progress in AD diagnosis by retinal examination. MDPI 2023-10-31 /pmc/articles/PMC10649108/ /pubmed/37958816 http://dx.doi.org/10.3390/ijms242115834 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review García-Bermúdez, Mariana Yolotzin Vohra, Rupali Freude, Kristine van Wijngaarden, Peter Martin, Keith Thomsen, Maj Schneider Aldana, Blanca Irene Kolko, Miriam Potential Retinal Biomarkers in Alzheimer’s Disease |
title | Potential Retinal Biomarkers in Alzheimer’s Disease |
title_full | Potential Retinal Biomarkers in Alzheimer’s Disease |
title_fullStr | Potential Retinal Biomarkers in Alzheimer’s Disease |
title_full_unstemmed | Potential Retinal Biomarkers in Alzheimer’s Disease |
title_short | Potential Retinal Biomarkers in Alzheimer’s Disease |
title_sort | potential retinal biomarkers in alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649108/ https://www.ncbi.nlm.nih.gov/pubmed/37958816 http://dx.doi.org/10.3390/ijms242115834 |
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