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The RAAS Goodfellas in Cardiovascular System

In the last two decades, the study of the renin–angiotensin–aldosterone system (RAAS) has revealed a counterregulatory protective axis. This protective arm is characterized by ACE2/Ang 1-7/MasR and Ang 1-9 that largely counteracts the classic arm of the RAAS mediated by ACE/Ang II/AT1R/aldosterone a...

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Autores principales: Caputo, Ilaria, Bertoldi, Giovanni, Driussi, Giulia, Cacciapuoti, Martina, Calò, Lorenzo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649249/
https://www.ncbi.nlm.nih.gov/pubmed/37959338
http://dx.doi.org/10.3390/jcm12216873
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author Caputo, Ilaria
Bertoldi, Giovanni
Driussi, Giulia
Cacciapuoti, Martina
Calò, Lorenzo A.
author_facet Caputo, Ilaria
Bertoldi, Giovanni
Driussi, Giulia
Cacciapuoti, Martina
Calò, Lorenzo A.
author_sort Caputo, Ilaria
collection PubMed
description In the last two decades, the study of the renin–angiotensin–aldosterone system (RAAS) has revealed a counterregulatory protective axis. This protective arm is characterized by ACE2/Ang 1-7/MasR and Ang 1-9 that largely counteracts the classic arm of the RAAS mediated by ACE/Ang II/AT1R/aldosterone and plays an important role in the prevention of inflammation, oxidative stress, hypertension, and cardiovascular remodeling. A growing body of evidence suggests that enhancement of this counterregulatory arm of RAAS represents an important therapeutic approach to facing cardiovascular comorbidities. In this review, we provide an overview of the beneficial effects of ACE2, Ang 1-7/MasR, and Ang 1-9 in the context of oxidative stress, vascular dysfunction, and organ damage.
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spelling pubmed-106492492023-10-31 The RAAS Goodfellas in Cardiovascular System Caputo, Ilaria Bertoldi, Giovanni Driussi, Giulia Cacciapuoti, Martina Calò, Lorenzo A. J Clin Med Review In the last two decades, the study of the renin–angiotensin–aldosterone system (RAAS) has revealed a counterregulatory protective axis. This protective arm is characterized by ACE2/Ang 1-7/MasR and Ang 1-9 that largely counteracts the classic arm of the RAAS mediated by ACE/Ang II/AT1R/aldosterone and plays an important role in the prevention of inflammation, oxidative stress, hypertension, and cardiovascular remodeling. A growing body of evidence suggests that enhancement of this counterregulatory arm of RAAS represents an important therapeutic approach to facing cardiovascular comorbidities. In this review, we provide an overview of the beneficial effects of ACE2, Ang 1-7/MasR, and Ang 1-9 in the context of oxidative stress, vascular dysfunction, and organ damage. MDPI 2023-10-31 /pmc/articles/PMC10649249/ /pubmed/37959338 http://dx.doi.org/10.3390/jcm12216873 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Caputo, Ilaria
Bertoldi, Giovanni
Driussi, Giulia
Cacciapuoti, Martina
Calò, Lorenzo A.
The RAAS Goodfellas in Cardiovascular System
title The RAAS Goodfellas in Cardiovascular System
title_full The RAAS Goodfellas in Cardiovascular System
title_fullStr The RAAS Goodfellas in Cardiovascular System
title_full_unstemmed The RAAS Goodfellas in Cardiovascular System
title_short The RAAS Goodfellas in Cardiovascular System
title_sort raas goodfellas in cardiovascular system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649249/
https://www.ncbi.nlm.nih.gov/pubmed/37959338
http://dx.doi.org/10.3390/jcm12216873
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