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A Single Injection of rAAV-shmTOR in Peripheral Nerve Persistently Attenuates Nerve Injury-Induced Mechanical Allodynia

Activation of mammalian target of rapamycin (mTOR) has been known as one of the contributing factors in nociceptive sensitization after peripheral injury. Its activation followed by the phosphorylation of downstream effectors causes hyperexcitability of primary sensory neurons in the dorsal root gan...

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Detalles Bibliográficos
Autores principales: Park, Minkyung, Woo, Ha-Na, Koh, Chin Su, Chang, Heesue, Kim, Ji Hyun, Park, Keerang, Chang, Jin Woo, Lee, Heuiran, Jung, Hyun Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649356/
https://www.ncbi.nlm.nih.gov/pubmed/37958901
http://dx.doi.org/10.3390/ijms242115918