Inhibitory Activity of 4-Benzylidene Oxazolones Derivatives of Cinnamic Acid on Human Acetylcholinesterase and Cognitive Improvements in a Mouse Model

We synthesized seven (Z)-benzylidene-2-(E)-styryloxazol-5(4H)-ones derivatives of cinnamic acid and evaluated the ability of these compounds to inhibit human acetylcholinesterase (hAChE). The most potent compound was evaluated for cognitive improvement in short-term memory. The seven compounds rever...

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Detalles Bibliográficos
Autores principales: Ramírez-Ruiz, Alma Marisol, Ávila-Cossío, Martha Elena, Estolano-Cobián, Arturo, Cornejo-Bravo, José Manuel, Martinez, Ana Laura, Córdova-Guerrero, Iván, Cota-Ramírez, Bibiana Roselly, Carranza-Ambriz, Krysta Paola, Rivero, Ignacio A., Serrano-Medina, Aracely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649417/
https://www.ncbi.nlm.nih.gov/pubmed/37959813
http://dx.doi.org/10.3390/molecules28217392

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