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Arrhythmia-Associated Calmodulin E105A Mutation Alters the Binding Affinity of CaM to a Ryanodine Receptor 2 CaM-Binding Pocket

Calmodulin (CaM) is a small, multifunctional calcium (Ca(2+))-binding sensor that binds and regulates the open probability of cardiac ryanodine receptor 2 (RyR2) at both low and high cytosolic Ca(2+) concentrations. Recent isothermal titration calorimetry (ITC) studies of a number of peptides that c...

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Detalles Bibliográficos
Autores principales:	Thanassoulas, Angelos, Theodoridou, Maria, Barrak, Laila, Riguene, Emna, Alyaarabi, Tamader, Elrayess, Mohamed A., Lai, F. Anthony, Nomikos, Michail
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649572/ https://www.ncbi.nlm.nih.gov/pubmed/37958614 http://dx.doi.org/10.3390/ijms242115630

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