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Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities
Background: Lichens are complex symbiotic associations between a fungus and an alga or cyanobacterium. Due to their great adaptability to the environment, they have managed to colonize many terrestrial habitats, presenting a worldwide distribution from the poles to the tropical regions and from the...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649588/ https://www.ncbi.nlm.nih.gov/pubmed/37959736 http://dx.doi.org/10.3390/molecules28217317 |
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author | Vega-Bello, María Jesús Moreno, Mari Luz Estellés-Leal, Rossana Hernández-Andreu, José Miguel Prieto-Ruiz, Jesús A. |
author_facet | Vega-Bello, María Jesús Moreno, Mari Luz Estellés-Leal, Rossana Hernández-Andreu, José Miguel Prieto-Ruiz, Jesús A. |
author_sort | Vega-Bello, María Jesús |
collection | PubMed |
description | Background: Lichens are complex symbiotic associations between a fungus and an alga or cyanobacterium. Due to their great adaptability to the environment, they have managed to colonize many terrestrial habitats, presenting a worldwide distribution from the poles to the tropical regions and from the plains to the highest mountains. In the flora of the Antarctic region, lichens stand out due to their variety and development and are a potential source of new bioactive compounds. Methods: A phytochemical study of the Antarctic lichen Usnea aurantiaco-atra (Jacq) Bory was conducted with the intention of determining the most important metabolites. In addition, the cytotoxic and antioxidant activities of its extracts were determined. Results: Cytotoxicity studies revealed that the hexane extract contains usnic acid as a majority metabolite, in addition to linoleic acid, ergosterols and terpenes, and demonstrates cytotoxic activity against an A375 melanoma cell line. On the other hand, the presence of total phenols in the extracts did not influence their antioxidant activity. Conclusions: U. aurantiaco-atra contains mainly usnic acid, although there are terpenes and ergosta compounds that could be responsible for its cytotoxic activity. The presence of phenols did not confer antioxidant properties. |
format | Online Article Text |
id | pubmed-10649588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106495882023-10-28 Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities Vega-Bello, María Jesús Moreno, Mari Luz Estellés-Leal, Rossana Hernández-Andreu, José Miguel Prieto-Ruiz, Jesús A. Molecules Article Background: Lichens are complex symbiotic associations between a fungus and an alga or cyanobacterium. Due to their great adaptability to the environment, they have managed to colonize many terrestrial habitats, presenting a worldwide distribution from the poles to the tropical regions and from the plains to the highest mountains. In the flora of the Antarctic region, lichens stand out due to their variety and development and are a potential source of new bioactive compounds. Methods: A phytochemical study of the Antarctic lichen Usnea aurantiaco-atra (Jacq) Bory was conducted with the intention of determining the most important metabolites. In addition, the cytotoxic and antioxidant activities of its extracts were determined. Results: Cytotoxicity studies revealed that the hexane extract contains usnic acid as a majority metabolite, in addition to linoleic acid, ergosterols and terpenes, and demonstrates cytotoxic activity against an A375 melanoma cell line. On the other hand, the presence of total phenols in the extracts did not influence their antioxidant activity. Conclusions: U. aurantiaco-atra contains mainly usnic acid, although there are terpenes and ergosta compounds that could be responsible for its cytotoxic activity. The presence of phenols did not confer antioxidant properties. MDPI 2023-10-28 /pmc/articles/PMC10649588/ /pubmed/37959736 http://dx.doi.org/10.3390/molecules28217317 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vega-Bello, María Jesús Moreno, Mari Luz Estellés-Leal, Rossana Hernández-Andreu, José Miguel Prieto-Ruiz, Jesús A. Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title | Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_full | Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_fullStr | Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_full_unstemmed | Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_short | Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_sort | usnea aurantiaco-atra (jacq) bory: metabolites and biological activities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649588/ https://www.ncbi.nlm.nih.gov/pubmed/37959736 http://dx.doi.org/10.3390/molecules28217317 |
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