Cytoplasmic-delivery of polyinosine-polycytidylic acid inhibits pancreatic cancer progression increasing survival by activating Stat1-CCL2-mediated immunity

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer without effective therapies and with poor prognosis, causing 7% of all cancer-related fatalities in the USA. Considering the lack of effective therapies for this aggressive cancer, there is an urgent need to define newer and...

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Detalles Bibliográficos
Autores principales: Bhoopathi, Praveen, Kumar, Amit, Pradhan, Anjan K, Maji, Santanu, Mannangatti, Padmanabhan, Windle, Jolene J, Subler, Mark A, Zhang, Dongyu, Vudatha, Vignesh, Trevino, Jose G, Madan, Esha, Atfi, Azeddine, Sarkar, Devanand, Gogna, Rajan, Das, Swadesh K, Emdad, Luni, Fisher, Paul B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649894/
https://www.ncbi.nlm.nih.gov/pubmed/37935566
http://dx.doi.org/10.1136/jitc-2023-007624

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