Systemic infusion of TLR3-ligand and IFN-α in patients with breast cancer reprograms local tumor microenvironments for selective CTL influx

BACKGROUND: Presence of cytotoxic T lymphocytes (CTL) in the tumor microenvironment (TME) predicts the effectiveness of cancer immunotherapies. The ability of toll-like receptor 3 (TLR3) ligands, interferons (IFNs) and COX2 inhibitors to synergistically induce CTL-attracting chemokines (but not regu...

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Detalles Bibliográficos
Autores principales: Gandhi, Shipra, Opyrchal, Mateusz, Grimm, Melissa J, Slomba, Ronald T, Kokolus, Kathleen M, Witkiewicz, Agnieszka, Attwood, Kristopher, Groman, Adrienne, Williams, Lauren, Tarquini, Mary Lynne, Wallace, Paul K, Soh, Kah Teong, Minderman, Hans, Maguire, Orla, O’Connor, Tracey L, Early, Amy P, Levine, Ellis G, Kalinski, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649898/
https://www.ncbi.nlm.nih.gov/pubmed/37963636
http://dx.doi.org/10.1136/jitc-2023-007381

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