Cargando…

Integration of Deep Learning and Sequential Metabolism to Rapidly Screen Dipeptidyl Peptidase (DPP)-IV Inhibitors from Gardenia jasminoides Ellis

Traditional Chinese medicine (TCM) possesses unique advantages in the management of blood glucose and lipids. However, there is still a significant gap in the exploration of its pharmacologically active components. Integrated strategies encompassing deep-learning prediction models and active validat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Huining, Yu, Shuang, Li, Xueyan, Wang, Xinyu, Qi, Dongying, Pan, Fulu, Chai, Xiaoyu, Wang, Qianqian, Pan, Yanli, Zhang, Lei, Liu, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649927/ https://www.ncbi.nlm.nih.gov/pubmed/37959800 http://dx.doi.org/10.3390/molecules28217381

Ejemplares similares

Recovery of Crocins From Floral Tissue of Gardenia jasminoides Ellis
por: Sommano, Sarana Rose, et al.
Publicado: (2020)

De novo transcriptome analysis of petal senescence in Gardenia jasminoides Ellis
por: Tsanakas, Georgios F, et al.
Publicado: (2014)

Multi-omics analysis reveals the molecular basis of flavonoid accumulation in fructus of Gardenia (Gardenia jasminoides Ellis)
por: Chen, Jianrong, et al.
Publicado: (2023)

Metabolomics integrated with transcriptomics reveals the distribution of iridoid and crocin metabolic flux in Gardenia jasminoides Ellis
por: Pan, Yuan, et al.
Publicado: (2021)

Metabolite Profiling of Gardenia jasminoides Ellis In Vitro Cultures with Different Levels of Differentiation
por: Krasteva, Gergana, et al.
Publicado: (2022)

Effective Therapeutic Verification of Crocin I, Geniposide, and Gardenia (Gardenia jasminoides Ellis) on Type 2 Diabetes Mellitus In Vivo and In Vitro
por: Zhou, Haibo, et al.
Publicado: (2023)

Evaluation of the suitability of Gardenia blue pigment derived from Gardenia jasminoides Ellis (Rubiaceae) as a dental plaque disclosant
por: Jung, Im‐hee, et al.
Publicado: (2022)

Ameliorative effects of melatonin on dark-induced leaf senescence in gardenia (Gardenia jasminoides Ellis): leaf morphology, anatomy, physiology and transcriptome
por: Zhao, Daqiu, et al.
Publicado: (2017)

Physicochemical and rheological characterization of pectin‐rich polysaccharides from Gardenia jasminoides J. Ellis flower
por: Chen, Qi, et al.
Publicado: (2020)

Rapid Antidepressant Activity of Ethanol Extract of Gardenia jasminoides Ellis Is Associated with Upregulation of BDNF Expression in the Hippocampus
por: Zhang, Hailou, et al.
Publicado: (2015)

Identification of Steroidogenic Components Derived From Gardenia jasminoides Ellis Potentially Useful for Treating Postmenopausal Syndrome
por: Wang, Xueyu, et al.
Publicado: (2018)

Genetic Authentication of Gardenia jasminoides Ellis var. grandiflora Nakai by Improved RAPD-Derived DNA Markers
por: Mei, Zhiqiang, et al.
Publicado: (2015)

Complete chloroplast genome of a wild-type Gardenia jasminoides ellis (rubiaceae) adapted to island climate
por: Zhang, Min, et al.
Publicado: (2021)

Conservation, Regeneration and Genetic Stability of Regenerants from Alginate-Encapsulated Shoot Explants of Gardenia jasminoides Ellis
por: Hatzilazarou, Stefanos, et al.
Publicado: (2021)

Chemistry and bioactivity of Gardenia jasminoides
por: Xiao, Wenping, et al.
Publicado: (2016)

Essential Oils of Gardenia jasminoides J. Ellis and Gardenia jasminoides f. longicarpa Z.W. Xie & M. Okada Flowers: Chemical Characterization and Assessment of Anti-Inflammatory Effects in Alveolar Macrophage
por: Zhang, Nan, et al.
Publicado: (2022)

Gardenia jasminoides Ellis Fruit Extracts Attenuated Colitis in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Rats
por: Liu, Jing, et al.
Publicado: (2021)

Downregulation of Signaling-active IGF-1 by Dipeptidyl Peptidase IV (DPP-IV)
por: Lin, Ching-Ting, et al.
Publicado: (2010)

The Effect of Various Media and Hormones via Suspension Culture on Secondary Metabolic Activities of (Cape Jasmine) Gardenia jasminoides Ellis
por: Farzinebrahimi, Reza, et al.
Publicado: (2014)

Behavioral Responses of Thrips hawaiiensis (Thysanoptera: Thripidae) to Volatile Compounds Identified from Gardenia jasminoides Ellis (Gentianales: Rubiaceae)
por: Cao, Yu, et al.
Publicado: (2020)

Genome-Wide Characterization and Analysis of bHLH Transcription Factors Related to Crocin Biosynthesis in Gardenia jasminoides Ellis (Rubiaceae)
por: Tian, Ya, et al.
Publicado: (2020)

Selective Extraction of Gardenia Yellow and Geniposide from Gardenia jasminoides by Mechanochemistry
por: Xu, Wenhao, et al.
Publicado: (2016)

Whole-genome resequencing analysis of the medicinal plant Gardenia jasminoides
por: Xu, Xinyu, et al.
Publicado: (2023)

Chemical Composition of Essential Oil from Flower of ‘Shanzhizi’ (Gardenia jasminoides Ellis) and Involvement of Serotonergic System in Its Anxiolytic Effect
por: Zhang, Nan, et al.
Publicado: (2020)

Disease Status–Dependent Drug–Herb Interactions: NASH Lowered the Risk of Hepatotoxicity in Rats Coadministered With Simvastatin and Gardenia jasminoides J. Ellis
por: Li, Ziwei, et al.
Publicado: (2021)

The Rapid and Long-Lasting Antidepressant Effects of Iridoid Fraction in Gardenia Jasminoides J.Ellis Are Dependent on Activating PKA-CREB Signaling Pathway
por: Ren, Li, et al.
Publicado: (2022)

Rapid Identification of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Ruditapes philippinarum Hydrolysate
por: Liu, Rui, et al.
Publicado: (2017)

Gardenia jasminoides J. Ellis extract GJ-4 attenuates hyperlipidemic vascular dementia in rats via regulating PPAR-γ-mediated microglial polarization
por: Liu, Hui, et al.
Publicado: (2022)

Simultaneous extraction of crocin and geniposide from gardenia fruits (Gardenia jasminoides Ellis) by probe-type ultrasound-assisted natural deep eutectic solvents and their inhibition effects on low density lipoprotein oxidation
por: Gan, Yuxin, et al.
Publicado: (2023)

Identification, Screening, and Comprehensive Evaluation of Novel DPP-IV Inhibitory Peptides from the Tilapia Skin Gelatin Hydrolysate Produced Using Ginger Protease
por: Liu, Wei, et al.
Publicado: (2022)

Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
por: Ługowska, Agnieszka, et al.
Publicado: (2021)

Evaluación de enraizadores y sustratos para la propagación de ixora coccinea l. y gardenia jasminoides ellis en Acayucan, Ver. /
por: López Torres, Beatriz Adriana
Publicado: (2009)

An Integrated Analysis Reveals Geniposide Extracted From Gardenia jasminoides J.Ellis Regulates Calcium Signaling Pathway Essential for Influenza A Virus Replication
por: Zhou, Lirun, et al.
Publicado: (2021)

Dipeptidyl peptidase-4 (DPP-4; CD26)
Publicado: (2013)

Peroxisome proliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extract and improvement of insulin sensitivity in steroid induced insulin resistant rats
por: Chen, Ying-I, et al.
Publicado: (2014)

Genotype–environment interaction of crocin in Gardenia jasminoides by AMMI and GGE biplot analysis
por: Liu, Qian, et al.
Publicado: (2022)

Inflammatory Response and Oxidative Stress as Mechanism of Reducing Hyperuricemia of Gardenia jasminoides-Poria cocos with Network Pharmacology
por: Liu, Lijun, et al.
Publicado: (2021)

Dipeptidyl peptidase-4 (DPP4) inhibition in COVID-19
por: Solerte, Sebastiano Bruno, et al.
Publicado: (2020)

Elucidation of Geniposide and Crocin Accumulation and Their Biosysnthsis-Related Key Enzymes during Gardenia jasminoides Fruit Growth
por: Zhang, Luhong, et al.
Publicado: (2023)

Monoamine Oxidase and Dopamine β-Hydroxylase Inhibitors from the Fruits of Gardenia jasminoides
por: Kim, Ji Ho, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nnp0bef25godc1hqjm3nqdoa9v