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An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair

The inability of wounds to heal effectively through normal repair has become a burden that seriously affects socio-economic development and human health. The therapy of acute and chronic skin wounds still poses great clinical difficulty due to the lack of suitable functional wound dressings. It has...

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Autores principales: Liang, Wenzi, Ni, Na, Huang, Yuxin, Lin, Changmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649939/
https://www.ncbi.nlm.nih.gov/pubmed/37959982
http://dx.doi.org/10.3390/polym15214301
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author Liang, Wenzi
Ni, Na
Huang, Yuxin
Lin, Changmin
author_facet Liang, Wenzi
Ni, Na
Huang, Yuxin
Lin, Changmin
author_sort Liang, Wenzi
collection PubMed
description The inability of wounds to heal effectively through normal repair has become a burden that seriously affects socio-economic development and human health. The therapy of acute and chronic skin wounds still poses great clinical difficulty due to the lack of suitable functional wound dressings. It has been found that dressings made of polyurethane exhibit excellent and diverse biological properties, but lack the functionality of clinical needs, and most dressings are unable to dynamically adapt to microenvironmental changes during the healing process at different stages of chronic wounds. Therefore, the development of multifunctional polyurethane composite materials has become a hot topic of research. This review describes the changes in physicochemical and biological properties caused by the incorporation of different polymers and fillers into polyurethane dressings and describes their applications in wound repair and regeneration. We listed several polymers, mainly including natural-based polymers (e.g., collagen, chitosan, and hyaluronic acid), synthetic-based polymers (e.g., polyethylene glycol, polyvinyl alcohol, and polyacrylamide), and some other active ingredients (e.g., LL37 peptide, platelet lysate, and exosomes). In addition to an introduction to the design and application of polyurethane-related dressings, we discuss the conversion and use of advanced functional dressings for applications, as well as future directions for development, providing reference for the development and new applications of novel polyurethane dressings.
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spelling pubmed-106499392023-11-01 An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair Liang, Wenzi Ni, Na Huang, Yuxin Lin, Changmin Polymers (Basel) Review The inability of wounds to heal effectively through normal repair has become a burden that seriously affects socio-economic development and human health. The therapy of acute and chronic skin wounds still poses great clinical difficulty due to the lack of suitable functional wound dressings. It has been found that dressings made of polyurethane exhibit excellent and diverse biological properties, but lack the functionality of clinical needs, and most dressings are unable to dynamically adapt to microenvironmental changes during the healing process at different stages of chronic wounds. Therefore, the development of multifunctional polyurethane composite materials has become a hot topic of research. This review describes the changes in physicochemical and biological properties caused by the incorporation of different polymers and fillers into polyurethane dressings and describes their applications in wound repair and regeneration. We listed several polymers, mainly including natural-based polymers (e.g., collagen, chitosan, and hyaluronic acid), synthetic-based polymers (e.g., polyethylene glycol, polyvinyl alcohol, and polyacrylamide), and some other active ingredients (e.g., LL37 peptide, platelet lysate, and exosomes). In addition to an introduction to the design and application of polyurethane-related dressings, we discuss the conversion and use of advanced functional dressings for applications, as well as future directions for development, providing reference for the development and new applications of novel polyurethane dressings. MDPI 2023-11-01 /pmc/articles/PMC10649939/ /pubmed/37959982 http://dx.doi.org/10.3390/polym15214301 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liang, Wenzi
Ni, Na
Huang, Yuxin
Lin, Changmin
An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
title An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
title_full An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
title_fullStr An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
title_full_unstemmed An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
title_short An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
title_sort advanced review: polyurethane-related dressings for skin wound repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649939/
https://www.ncbi.nlm.nih.gov/pubmed/37959982
http://dx.doi.org/10.3390/polym15214301
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