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An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair
The inability of wounds to heal effectively through normal repair has become a burden that seriously affects socio-economic development and human health. The therapy of acute and chronic skin wounds still poses great clinical difficulty due to the lack of suitable functional wound dressings. It has...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649939/ https://www.ncbi.nlm.nih.gov/pubmed/37959982 http://dx.doi.org/10.3390/polym15214301 |
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author | Liang, Wenzi Ni, Na Huang, Yuxin Lin, Changmin |
author_facet | Liang, Wenzi Ni, Na Huang, Yuxin Lin, Changmin |
author_sort | Liang, Wenzi |
collection | PubMed |
description | The inability of wounds to heal effectively through normal repair has become a burden that seriously affects socio-economic development and human health. The therapy of acute and chronic skin wounds still poses great clinical difficulty due to the lack of suitable functional wound dressings. It has been found that dressings made of polyurethane exhibit excellent and diverse biological properties, but lack the functionality of clinical needs, and most dressings are unable to dynamically adapt to microenvironmental changes during the healing process at different stages of chronic wounds. Therefore, the development of multifunctional polyurethane composite materials has become a hot topic of research. This review describes the changes in physicochemical and biological properties caused by the incorporation of different polymers and fillers into polyurethane dressings and describes their applications in wound repair and regeneration. We listed several polymers, mainly including natural-based polymers (e.g., collagen, chitosan, and hyaluronic acid), synthetic-based polymers (e.g., polyethylene glycol, polyvinyl alcohol, and polyacrylamide), and some other active ingredients (e.g., LL37 peptide, platelet lysate, and exosomes). In addition to an introduction to the design and application of polyurethane-related dressings, we discuss the conversion and use of advanced functional dressings for applications, as well as future directions for development, providing reference for the development and new applications of novel polyurethane dressings. |
format | Online Article Text |
id | pubmed-10649939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106499392023-11-01 An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair Liang, Wenzi Ni, Na Huang, Yuxin Lin, Changmin Polymers (Basel) Review The inability of wounds to heal effectively through normal repair has become a burden that seriously affects socio-economic development and human health. The therapy of acute and chronic skin wounds still poses great clinical difficulty due to the lack of suitable functional wound dressings. It has been found that dressings made of polyurethane exhibit excellent and diverse biological properties, but lack the functionality of clinical needs, and most dressings are unable to dynamically adapt to microenvironmental changes during the healing process at different stages of chronic wounds. Therefore, the development of multifunctional polyurethane composite materials has become a hot topic of research. This review describes the changes in physicochemical and biological properties caused by the incorporation of different polymers and fillers into polyurethane dressings and describes their applications in wound repair and regeneration. We listed several polymers, mainly including natural-based polymers (e.g., collagen, chitosan, and hyaluronic acid), synthetic-based polymers (e.g., polyethylene glycol, polyvinyl alcohol, and polyacrylamide), and some other active ingredients (e.g., LL37 peptide, platelet lysate, and exosomes). In addition to an introduction to the design and application of polyurethane-related dressings, we discuss the conversion and use of advanced functional dressings for applications, as well as future directions for development, providing reference for the development and new applications of novel polyurethane dressings. MDPI 2023-11-01 /pmc/articles/PMC10649939/ /pubmed/37959982 http://dx.doi.org/10.3390/polym15214301 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liang, Wenzi Ni, Na Huang, Yuxin Lin, Changmin An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair |
title | An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair |
title_full | An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair |
title_fullStr | An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair |
title_full_unstemmed | An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair |
title_short | An Advanced Review: Polyurethane-Related Dressings for Skin Wound Repair |
title_sort | advanced review: polyurethane-related dressings for skin wound repair |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649939/ https://www.ncbi.nlm.nih.gov/pubmed/37959982 http://dx.doi.org/10.3390/polym15214301 |
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