A Generative Adversarial Network to Synthesize 3D Magnetohydrodynamic Distortions for Electrocardiogram Analyses Applied to Cardiac Magnetic Resonance Imaging

Recently, deep learning (DL) models have been increasingly adopted for automatic analyses of medical data, including electrocardiograms (ECGs). Large, available ECG datasets, generally of high quality, often lack specific distortions, which could be helpful for enhancing DL-based algorithms. Synthetic ECG datasets could overcome this limitation. A generative adversarial network (GAN) was used to synthesize realistic 3D magnetohydrodynamic (MHD) distortion templates, as observed during magnetic resonance imaging (MRI), and then added to available ECG recordings to produce an augmented dataset. Similarity metrics, as well as the accuracy of a DL-based R-peak detector trained with and without data augmentation, were used to evaluate the effectiveness of the synthesized data. Three-dimensional MHD distortions produced by the proposed GAN were similar to the measured ones used as input. The precision of a DL-based R-peak detector, tested on actual unseen data, was significantly enhanced by data augmentation; its recall was higher when trained with augmented data. Using synthesized MHD-distorted ECGs significantly improves the accuracy of a DL-based R-peak detector, with a good generalization capacity. This provides a simple and effective alternative to collecting new patient data. DL-based algorithms for ECG analyses can suffer from bias or gaps in training datasets. Using a GAN to synthesize new data, as well as metrics to evaluate its performance, can overcome the scarcity issue of data availability.