Cargando…
The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer
The human CERS2 gene encodes a ceramide synthase enzyme, known as CERS2 (ceramide synthase 2). This protein is also known as LASS2 (LAG1 longevity assurance homolog 2) and TMSG1 (tumor metastasis-suppressor gene 1). Although previously described as a tumor suppressor for different types of cancer, s...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650086/ https://www.ncbi.nlm.nih.gov/pubmed/37958652 http://dx.doi.org/10.3390/ijms242115668 |
_version_ | 1785135699101483008 |
---|---|
author | Garcia-Vallicrosa, Clara Falcon-Perez, Juan M. Royo, Felix |
author_facet | Garcia-Vallicrosa, Clara Falcon-Perez, Juan M. Royo, Felix |
author_sort | Garcia-Vallicrosa, Clara |
collection | PubMed |
description | The human CERS2 gene encodes a ceramide synthase enzyme, known as CERS2 (ceramide synthase 2). This protein is also known as LASS2 (LAG1 longevity assurance homolog 2) and TMSG1 (tumor metastasis-suppressor gene 1). Although previously described as a tumor suppressor for different types of cancer, such as prostate or liver cancer, it has also been observed to promote tumor growth in adenocarcinoma. In this review, we focus on the influence of CERS2 in bladder cancer (BC), approaching the existing literature about its structure and activity, as well as the miRNAs regulating its expression. From a mechanistic point of view, different explanations for the role of CERS2 as an antitumor protein have been proposed, including the production of long-chain ceramides, interaction with vacuolar ATPase, and its function as inhibitor of mitochondrial fission. In addition, we reviewed the literature specifically studying the expression of this gene in both BC and biopsy-derived tumor cell lines, complementing this with an analysis of public gene expression data and its association with disease progression. We also discuss the importance of CERS2 as a biomarker and the presence of CERS2 mRNA in extracellular vesicles isolated from urine. |
format | Online Article Text |
id | pubmed-10650086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106500862023-10-27 The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer Garcia-Vallicrosa, Clara Falcon-Perez, Juan M. Royo, Felix Int J Mol Sci Review The human CERS2 gene encodes a ceramide synthase enzyme, known as CERS2 (ceramide synthase 2). This protein is also known as LASS2 (LAG1 longevity assurance homolog 2) and TMSG1 (tumor metastasis-suppressor gene 1). Although previously described as a tumor suppressor for different types of cancer, such as prostate or liver cancer, it has also been observed to promote tumor growth in adenocarcinoma. In this review, we focus on the influence of CERS2 in bladder cancer (BC), approaching the existing literature about its structure and activity, as well as the miRNAs regulating its expression. From a mechanistic point of view, different explanations for the role of CERS2 as an antitumor protein have been proposed, including the production of long-chain ceramides, interaction with vacuolar ATPase, and its function as inhibitor of mitochondrial fission. In addition, we reviewed the literature specifically studying the expression of this gene in both BC and biopsy-derived tumor cell lines, complementing this with an analysis of public gene expression data and its association with disease progression. We also discuss the importance of CERS2 as a biomarker and the presence of CERS2 mRNA in extracellular vesicles isolated from urine. MDPI 2023-10-27 /pmc/articles/PMC10650086/ /pubmed/37958652 http://dx.doi.org/10.3390/ijms242115668 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Garcia-Vallicrosa, Clara Falcon-Perez, Juan M. Royo, Felix The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer |
title | The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer |
title_full | The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer |
title_fullStr | The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer |
title_full_unstemmed | The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer |
title_short | The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer |
title_sort | role of longevity assurance homolog 2/ceramide synthase 2 in bladder cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650086/ https://www.ncbi.nlm.nih.gov/pubmed/37958652 http://dx.doi.org/10.3390/ijms242115668 |
work_keys_str_mv | AT garciavallicrosaclara theroleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer AT falconperezjuanm theroleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer AT royofelix theroleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer AT garciavallicrosaclara roleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer AT falconperezjuanm roleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer AT royofelix roleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer |