Cargando…

The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer

The human CERS2 gene encodes a ceramide synthase enzyme, known as CERS2 (ceramide synthase 2). This protein is also known as LASS2 (LAG1 longevity assurance homolog 2) and TMSG1 (tumor metastasis-suppressor gene 1). Although previously described as a tumor suppressor for different types of cancer, s...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcia-Vallicrosa, Clara, Falcon-Perez, Juan M., Royo, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650086/
https://www.ncbi.nlm.nih.gov/pubmed/37958652
http://dx.doi.org/10.3390/ijms242115668
_version_ 1785135699101483008
author Garcia-Vallicrosa, Clara
Falcon-Perez, Juan M.
Royo, Felix
author_facet Garcia-Vallicrosa, Clara
Falcon-Perez, Juan M.
Royo, Felix
author_sort Garcia-Vallicrosa, Clara
collection PubMed
description The human CERS2 gene encodes a ceramide synthase enzyme, known as CERS2 (ceramide synthase 2). This protein is also known as LASS2 (LAG1 longevity assurance homolog 2) and TMSG1 (tumor metastasis-suppressor gene 1). Although previously described as a tumor suppressor for different types of cancer, such as prostate or liver cancer, it has also been observed to promote tumor growth in adenocarcinoma. In this review, we focus on the influence of CERS2 in bladder cancer (BC), approaching the existing literature about its structure and activity, as well as the miRNAs regulating its expression. From a mechanistic point of view, different explanations for the role of CERS2 as an antitumor protein have been proposed, including the production of long-chain ceramides, interaction with vacuolar ATPase, and its function as inhibitor of mitochondrial fission. In addition, we reviewed the literature specifically studying the expression of this gene in both BC and biopsy-derived tumor cell lines, complementing this with an analysis of public gene expression data and its association with disease progression. We also discuss the importance of CERS2 as a biomarker and the presence of CERS2 mRNA in extracellular vesicles isolated from urine.
format Online
Article
Text
id pubmed-10650086
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106500862023-10-27 The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer Garcia-Vallicrosa, Clara Falcon-Perez, Juan M. Royo, Felix Int J Mol Sci Review The human CERS2 gene encodes a ceramide synthase enzyme, known as CERS2 (ceramide synthase 2). This protein is also known as LASS2 (LAG1 longevity assurance homolog 2) and TMSG1 (tumor metastasis-suppressor gene 1). Although previously described as a tumor suppressor for different types of cancer, such as prostate or liver cancer, it has also been observed to promote tumor growth in adenocarcinoma. In this review, we focus on the influence of CERS2 in bladder cancer (BC), approaching the existing literature about its structure and activity, as well as the miRNAs regulating its expression. From a mechanistic point of view, different explanations for the role of CERS2 as an antitumor protein have been proposed, including the production of long-chain ceramides, interaction with vacuolar ATPase, and its function as inhibitor of mitochondrial fission. In addition, we reviewed the literature specifically studying the expression of this gene in both BC and biopsy-derived tumor cell lines, complementing this with an analysis of public gene expression data and its association with disease progression. We also discuss the importance of CERS2 as a biomarker and the presence of CERS2 mRNA in extracellular vesicles isolated from urine. MDPI 2023-10-27 /pmc/articles/PMC10650086/ /pubmed/37958652 http://dx.doi.org/10.3390/ijms242115668 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Garcia-Vallicrosa, Clara
Falcon-Perez, Juan M.
Royo, Felix
The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer
title The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer
title_full The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer
title_fullStr The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer
title_full_unstemmed The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer
title_short The Role of Longevity Assurance Homolog 2/Ceramide Synthase 2 in Bladder Cancer
title_sort role of longevity assurance homolog 2/ceramide synthase 2 in bladder cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650086/
https://www.ncbi.nlm.nih.gov/pubmed/37958652
http://dx.doi.org/10.3390/ijms242115668
work_keys_str_mv AT garciavallicrosaclara theroleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer
AT falconperezjuanm theroleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer
AT royofelix theroleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer
AT garciavallicrosaclara roleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer
AT falconperezjuanm roleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer
AT royofelix roleoflongevityassurancehomolog2ceramidesynthase2inbladdercancer