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Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach

The literature shows how sarcopenia often occurs along with different phenotypes based either on the concomitant presence of adipose tissue excess (i.e., sarcopenic obesity, SO), or osteopenia/osteoporosis (osteosarcopenia, OS), or the combination of the two conditions, so-called osteosarcopenic obe...

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Autores principales: Moroni, Alessia, Perna, Simone, Azzolino, Domenico, Gasparri, Clara, Zupo, Roberta, Micheletti Cremasco, Margherita, Rondanelli, Mariangela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650113/
https://www.ncbi.nlm.nih.gov/pubmed/37960189
http://dx.doi.org/10.3390/nu15214536
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author Moroni, Alessia
Perna, Simone
Azzolino, Domenico
Gasparri, Clara
Zupo, Roberta
Micheletti Cremasco, Margherita
Rondanelli, Mariangela
author_facet Moroni, Alessia
Perna, Simone
Azzolino, Domenico
Gasparri, Clara
Zupo, Roberta
Micheletti Cremasco, Margherita
Rondanelli, Mariangela
author_sort Moroni, Alessia
collection PubMed
description The literature shows how sarcopenia often occurs along with different phenotypes based either on the concomitant presence of adipose tissue excess (i.e., sarcopenic obesity, SO), or osteopenia/osteoporosis (osteosarcopenia, OS), or the combination of the two conditions, so-called osteosarcopenic obesity (OSO). This research aimed to assess the prevalence of sarcopenia phenotypes (SO, OS, OSO), their associated risk factors and their health impact in a population of out- and inpatients living in the North of Italy. Male and female subjects aged ≥18 years were enrolled for the study. A blood sample was collected to measure targeted blood makers. A comprehensive anthropometric clinical assessment (height, weight, Body Mass Index, BMI and Dual Energy X-ray Absorptiometry, DXA) was performed to measure ponderal, bone, fat, and muscle status. A total of 1510 individuals participated to the study (females, n = 1100; 72.85%). Sarcopenia was the most prevalent phenotype (17%), followed by osteosarcopenia (14.7%) and sarcopenic obesity. Only 1.9% of the sample was affected by OSO. According to logistic regression analysis, sarcopenia was associated with age, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) (positively) and BMI, Iron (Fe), Total Cholesterol, albumin (%), albumin (g), and gamma proteins (negatively). Sarcopenic obesity was associated with age, ferritin, ESR, CRP (positively) and BMI, Fe, and albumin (%) (negatively). Osteosarcopenia was associated with age, ESR (positively) and BMI, Total Cholesterol, albumin (%), albumin (g), and Ca (negatively). Osteosarcopenic obesity was associated with glycemia and gamma-glutamyl transferase (gGT) (positively). According to random forest analysis, a higher BMI was the most important protective factor for sarcopenia, for sarcopenic obesity (along with Iron) and for osteosarcopenia (along with albumin). Moreover, osteosarcopenic obesity was positively associated with GgT and glycaemia. The possibility of gaining such information, especially in the younger population, could help to prevent the onset of such diseases and best fit the patient’s needs, according to a precision-medicine approach.
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spelling pubmed-106501132023-10-26 Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach Moroni, Alessia Perna, Simone Azzolino, Domenico Gasparri, Clara Zupo, Roberta Micheletti Cremasco, Margherita Rondanelli, Mariangela Nutrients Article The literature shows how sarcopenia often occurs along with different phenotypes based either on the concomitant presence of adipose tissue excess (i.e., sarcopenic obesity, SO), or osteopenia/osteoporosis (osteosarcopenia, OS), or the combination of the two conditions, so-called osteosarcopenic obesity (OSO). This research aimed to assess the prevalence of sarcopenia phenotypes (SO, OS, OSO), their associated risk factors and their health impact in a population of out- and inpatients living in the North of Italy. Male and female subjects aged ≥18 years were enrolled for the study. A blood sample was collected to measure targeted blood makers. A comprehensive anthropometric clinical assessment (height, weight, Body Mass Index, BMI and Dual Energy X-ray Absorptiometry, DXA) was performed to measure ponderal, bone, fat, and muscle status. A total of 1510 individuals participated to the study (females, n = 1100; 72.85%). Sarcopenia was the most prevalent phenotype (17%), followed by osteosarcopenia (14.7%) and sarcopenic obesity. Only 1.9% of the sample was affected by OSO. According to logistic regression analysis, sarcopenia was associated with age, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) (positively) and BMI, Iron (Fe), Total Cholesterol, albumin (%), albumin (g), and gamma proteins (negatively). Sarcopenic obesity was associated with age, ferritin, ESR, CRP (positively) and BMI, Fe, and albumin (%) (negatively). Osteosarcopenia was associated with age, ESR (positively) and BMI, Total Cholesterol, albumin (%), albumin (g), and Ca (negatively). Osteosarcopenic obesity was associated with glycemia and gamma-glutamyl transferase (gGT) (positively). According to random forest analysis, a higher BMI was the most important protective factor for sarcopenia, for sarcopenic obesity (along with Iron) and for osteosarcopenia (along with albumin). Moreover, osteosarcopenic obesity was positively associated with GgT and glycaemia. The possibility of gaining such information, especially in the younger population, could help to prevent the onset of such diseases and best fit the patient’s needs, according to a precision-medicine approach. MDPI 2023-10-26 /pmc/articles/PMC10650113/ /pubmed/37960189 http://dx.doi.org/10.3390/nu15214536 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moroni, Alessia
Perna, Simone
Azzolino, Domenico
Gasparri, Clara
Zupo, Roberta
Micheletti Cremasco, Margherita
Rondanelli, Mariangela
Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach
title Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach
title_full Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach
title_fullStr Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach
title_full_unstemmed Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach
title_short Discovering the Individualized Factors Associated with Sarcopenia and Sarcopenic Obesity Phenotypes—A Machine Learning Approach
title_sort discovering the individualized factors associated with sarcopenia and sarcopenic obesity phenotypes—a machine learning approach
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650113/
https://www.ncbi.nlm.nih.gov/pubmed/37960189
http://dx.doi.org/10.3390/nu15214536
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