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Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease

Patients with chronic obstructive pulmonary disease (COPD) may experience exacerbations. During severe exacerbations, nutritional and endocrinological comorbidities can play an important role in the clinical and functional aspects of these patients. The aim of this study was to analyse the influence...

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Autores principales: Correa-Gutiérrez, Cristhian Alonso, Ji, Zichen, Aragón-Espinosa, Patricia, Rodrigues-Oliveira, Sarah, Zeng, Luyi, Meizoso-Pita, Olalla, Sevillano-Collantes, Cristina, Hernández-Vázquez, Julio, Puente-Maestu, Luis, de Miguel-Díez, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650144/
https://www.ncbi.nlm.nih.gov/pubmed/37959339
http://dx.doi.org/10.3390/jcm12216874
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author Correa-Gutiérrez, Cristhian Alonso
Ji, Zichen
Aragón-Espinosa, Patricia
Rodrigues-Oliveira, Sarah
Zeng, Luyi
Meizoso-Pita, Olalla
Sevillano-Collantes, Cristina
Hernández-Vázquez, Julio
Puente-Maestu, Luis
de Miguel-Díez, Javier
author_facet Correa-Gutiérrez, Cristhian Alonso
Ji, Zichen
Aragón-Espinosa, Patricia
Rodrigues-Oliveira, Sarah
Zeng, Luyi
Meizoso-Pita, Olalla
Sevillano-Collantes, Cristina
Hernández-Vázquez, Julio
Puente-Maestu, Luis
de Miguel-Díez, Javier
author_sort Correa-Gutiérrez, Cristhian Alonso
collection PubMed
description Patients with chronic obstructive pulmonary disease (COPD) may experience exacerbations. During severe exacerbations, nutritional and endocrinological comorbidities can play an important role in the clinical and functional aspects of these patients. The aim of this study was to analyse the influence of the presence of diabetes mellitus (DM) and nutritional parameters on the deterioration of symptoms and quality of life during a severe exacerbation in patients with COPD. An observational study was conducted on COPD patients admitted due to an exacerbation. The COPD Assessment Test (CAT) questionnaire was administered, and clinical and functional parameters were compared based on the presence of nutritional and endocrinological alterations. A total of 50 patients were included, of whom 30 (60%) were male. The mean age was 70.5 years (standard deviation (SD) 9.6). The median CAT score during exacerbation was 25 (interquartile range (IQR) 17.5–30), and the baseline score was 13.5 (IQR 7–19), which represented a statistically significant difference (p < 0.001). Patients with iron deficiencies had a lower total CAT score (p = 0.041), specifically for items related to daily activity (p = 0.009) and energy (p = 0.007). Diabetic patients exhibited a greater decline in pulmonary function during exacerbation (p = 0.016), while patients with high thyroid-stimulating hormone (TSH) levels had a shorter hospital stay (p = 0.016). For COPD patients admitted due to an exacerbation, the metabolic assessment is useful and relevant in the clinical set-up, as endocrinological comorbidities negatively affect clinical and functional aspects of these patients.
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spelling pubmed-106501442023-10-31 Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease Correa-Gutiérrez, Cristhian Alonso Ji, Zichen Aragón-Espinosa, Patricia Rodrigues-Oliveira, Sarah Zeng, Luyi Meizoso-Pita, Olalla Sevillano-Collantes, Cristina Hernández-Vázquez, Julio Puente-Maestu, Luis de Miguel-Díez, Javier J Clin Med Article Patients with chronic obstructive pulmonary disease (COPD) may experience exacerbations. During severe exacerbations, nutritional and endocrinological comorbidities can play an important role in the clinical and functional aspects of these patients. The aim of this study was to analyse the influence of the presence of diabetes mellitus (DM) and nutritional parameters on the deterioration of symptoms and quality of life during a severe exacerbation in patients with COPD. An observational study was conducted on COPD patients admitted due to an exacerbation. The COPD Assessment Test (CAT) questionnaire was administered, and clinical and functional parameters were compared based on the presence of nutritional and endocrinological alterations. A total of 50 patients were included, of whom 30 (60%) were male. The mean age was 70.5 years (standard deviation (SD) 9.6). The median CAT score during exacerbation was 25 (interquartile range (IQR) 17.5–30), and the baseline score was 13.5 (IQR 7–19), which represented a statistically significant difference (p < 0.001). Patients with iron deficiencies had a lower total CAT score (p = 0.041), specifically for items related to daily activity (p = 0.009) and energy (p = 0.007). Diabetic patients exhibited a greater decline in pulmonary function during exacerbation (p = 0.016), while patients with high thyroid-stimulating hormone (TSH) levels had a shorter hospital stay (p = 0.016). For COPD patients admitted due to an exacerbation, the metabolic assessment is useful and relevant in the clinical set-up, as endocrinological comorbidities negatively affect clinical and functional aspects of these patients. MDPI 2023-10-31 /pmc/articles/PMC10650144/ /pubmed/37959339 http://dx.doi.org/10.3390/jcm12216874 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Correa-Gutiérrez, Cristhian Alonso
Ji, Zichen
Aragón-Espinosa, Patricia
Rodrigues-Oliveira, Sarah
Zeng, Luyi
Meizoso-Pita, Olalla
Sevillano-Collantes, Cristina
Hernández-Vázquez, Julio
Puente-Maestu, Luis
de Miguel-Díez, Javier
Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease
title Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease
title_full Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease
title_fullStr Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease
title_full_unstemmed Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease
title_short Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease
title_sort influence of diabetes mellitus and nutritional parameters on clinical and functional aspects and quality of life in patients hospitalized due to exacerbation of chronic obstructive pulmonary disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650144/
https://www.ncbi.nlm.nih.gov/pubmed/37959339
http://dx.doi.org/10.3390/jcm12216874
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