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Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock
INTRODUCTION: Chronic alcoholic patients have a threefold to fourfold increased risk for developing a severe infection or septic shock after surgery, which might be due to altered immune response. The aim of this outcome matched study was to investigate proinflammatory and anti-inflammatory immune p...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065020/ https://www.ncbi.nlm.nih.gov/pubmed/15469574 http://dx.doi.org/10.1186/cc2911 |
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author | von Dossow, Vera Schilling, Corinna Beller, Stefan Hein, Ortrud Vargas von Heymann, Christian Kox, Wolfgang J Spies, Claudia D |
author_facet | von Dossow, Vera Schilling, Corinna Beller, Stefan Hein, Ortrud Vargas von Heymann, Christian Kox, Wolfgang J Spies, Claudia D |
author_sort | von Dossow, Vera |
collection | PubMed |
description | INTRODUCTION: Chronic alcoholic patients have a threefold to fourfold increased risk for developing a severe infection or septic shock after surgery, which might be due to altered immune response. The aim of this outcome matched study was to investigate proinflammatory and anti-inflammatory immune parameters during the course of infection and subsequent septic shock in chronic alcoholic patients, and to compare these parameters with those in nonalcoholic patients. METHODS: Twenty-eight patients from a cohort of fifty-six with either pneumonia or peritonitis and subsequent septic shock were selected. Fourteen patients were chronic alcoholics whereas fourteen were nonalcoholic patients. Chronic alcoholic patients met criteria (Diagnostic and Statistical Manual of Mental Disorders IV, of the American Psychiatric Association) for alcohol abuse or dependence. Measurements were performed during the onset of infection (within 24 hours after the onset of infection), in early septic shock (within 12 hours after onset of septic shock) and in late septic shock (72 hours after the onset). Blood measurements included proinflammatory and anti-inflammatory cytokines. RESULTS: Chronic alcoholic patients exhibited significantly lower plasma levels of IL-8 (P < 0.010) during the onset of infection than did matched nonalcoholic patients. In early septic shock, chronic alcoholic patients had significantly decreased levels of IL-1β (P < 0.015), IL-6 (P < 0.016) and IL-8 (P < 0.010). The anti-inflammatory parameters IL-10 and tumour necrosis factor receptors I and II did not differ between alcoholic and nonalcoholic patients. CONCLUSION: At the onset of infection and during early septic shock, chronic alcoholic patients had lower levels of proinflammatory immune parameters than did nonalcoholic patients. Therefore, immunomodulatory therapy administered early may be considered in chronic alcoholic patients at the onset of an infection because of their altered proinflammatory immune response. |
format | Text |
id | pubmed-1065020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-10650202005-03-16 Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock von Dossow, Vera Schilling, Corinna Beller, Stefan Hein, Ortrud Vargas von Heymann, Christian Kox, Wolfgang J Spies, Claudia D Crit Care Research INTRODUCTION: Chronic alcoholic patients have a threefold to fourfold increased risk for developing a severe infection or septic shock after surgery, which might be due to altered immune response. The aim of this outcome matched study was to investigate proinflammatory and anti-inflammatory immune parameters during the course of infection and subsequent septic shock in chronic alcoholic patients, and to compare these parameters with those in nonalcoholic patients. METHODS: Twenty-eight patients from a cohort of fifty-six with either pneumonia or peritonitis and subsequent septic shock were selected. Fourteen patients were chronic alcoholics whereas fourteen were nonalcoholic patients. Chronic alcoholic patients met criteria (Diagnostic and Statistical Manual of Mental Disorders IV, of the American Psychiatric Association) for alcohol abuse or dependence. Measurements were performed during the onset of infection (within 24 hours after the onset of infection), in early septic shock (within 12 hours after onset of septic shock) and in late septic shock (72 hours after the onset). Blood measurements included proinflammatory and anti-inflammatory cytokines. RESULTS: Chronic alcoholic patients exhibited significantly lower plasma levels of IL-8 (P < 0.010) during the onset of infection than did matched nonalcoholic patients. In early septic shock, chronic alcoholic patients had significantly decreased levels of IL-1β (P < 0.015), IL-6 (P < 0.016) and IL-8 (P < 0.010). The anti-inflammatory parameters IL-10 and tumour necrosis factor receptors I and II did not differ between alcoholic and nonalcoholic patients. CONCLUSION: At the onset of infection and during early septic shock, chronic alcoholic patients had lower levels of proinflammatory immune parameters than did nonalcoholic patients. Therefore, immunomodulatory therapy administered early may be considered in chronic alcoholic patients at the onset of an infection because of their altered proinflammatory immune response. BioMed Central 2004 2004-07-20 /pmc/articles/PMC1065020/ /pubmed/15469574 http://dx.doi.org/10.1186/cc2911 Text en Copyright © 2004 Dossow et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL |
spellingShingle | Research von Dossow, Vera Schilling, Corinna Beller, Stefan Hein, Ortrud Vargas von Heymann, Christian Kox, Wolfgang J Spies, Claudia D Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock |
title | Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock |
title_full | Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock |
title_fullStr | Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock |
title_full_unstemmed | Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock |
title_short | Altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock |
title_sort | altered immune parameters in chronic alcoholic patients at the onset of infection and of septic shock |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065020/ https://www.ncbi.nlm.nih.gov/pubmed/15469574 http://dx.doi.org/10.1186/cc2911 |
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