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The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer’s disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the western dietary context is the high consumption o...

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Autores principales: Ungvari, Anna, Gulej, Rafal, Csik, Boglarka, Mukli, Peter, Negri, Sharon, Tarantini, Stefano, Yabluchanskiy, Andriy, Benyo, Zoltan, Csiszar, Anna, Ungvari, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650229/
https://www.ncbi.nlm.nih.gov/pubmed/37960316
http://dx.doi.org/10.3390/nu15214662
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author Ungvari, Anna
Gulej, Rafal
Csik, Boglarka
Mukli, Peter
Negri, Sharon
Tarantini, Stefano
Yabluchanskiy, Andriy
Benyo, Zoltan
Csiszar, Anna
Ungvari, Zoltan
author_facet Ungvari, Anna
Gulej, Rafal
Csik, Boglarka
Mukli, Peter
Negri, Sharon
Tarantini, Stefano
Yabluchanskiy, Andriy
Benyo, Zoltan
Csiszar, Anna
Ungvari, Zoltan
author_sort Ungvari, Anna
collection PubMed
description As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer’s disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the western dietary context is the high consumption of methionine-rich foods such as red meat. The present review delves into the impact of this methionine-heavy diet and the resultant hyperhomocysteinemia on accelerated cerebrovascular and brain aging, emphasizing their potential roles in cognitive impairment. Through a comprehensive exploration of existing evidence, a link between high methionine intake and hyperhomocysteinemia and oxidative stress, mitochondrial dysfunction, inflammation, and accelerated epigenetic aging is drawn. Moreover, the microvascular determinants of cognitive deterioration, including endothelial dysfunction, reduced cerebral blood flow, microvascular rarefaction, impaired neurovascular coupling, and blood–brain barrier (BBB) disruption, are explored. The mechanisms by which excessive methionine consumption and hyperhomocysteinemia might drive cerebromicrovascular and brain aging processes are elucidated. By presenting an intricate understanding of the relationships among methionine-rich diets, hyperhomocysteinemia, cerebrovascular and brain aging, and cognitive impairment, avenues for future research and potential therapeutic interventions are suggested.
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spelling pubmed-106502292023-11-03 The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment Ungvari, Anna Gulej, Rafal Csik, Boglarka Mukli, Peter Negri, Sharon Tarantini, Stefano Yabluchanskiy, Andriy Benyo, Zoltan Csiszar, Anna Ungvari, Zoltan Nutrients Review As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer’s disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the western dietary context is the high consumption of methionine-rich foods such as red meat. The present review delves into the impact of this methionine-heavy diet and the resultant hyperhomocysteinemia on accelerated cerebrovascular and brain aging, emphasizing their potential roles in cognitive impairment. Through a comprehensive exploration of existing evidence, a link between high methionine intake and hyperhomocysteinemia and oxidative stress, mitochondrial dysfunction, inflammation, and accelerated epigenetic aging is drawn. Moreover, the microvascular determinants of cognitive deterioration, including endothelial dysfunction, reduced cerebral blood flow, microvascular rarefaction, impaired neurovascular coupling, and blood–brain barrier (BBB) disruption, are explored. The mechanisms by which excessive methionine consumption and hyperhomocysteinemia might drive cerebromicrovascular and brain aging processes are elucidated. By presenting an intricate understanding of the relationships among methionine-rich diets, hyperhomocysteinemia, cerebrovascular and brain aging, and cognitive impairment, avenues for future research and potential therapeutic interventions are suggested. MDPI 2023-11-03 /pmc/articles/PMC10650229/ /pubmed/37960316 http://dx.doi.org/10.3390/nu15214662 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ungvari, Anna
Gulej, Rafal
Csik, Boglarka
Mukli, Peter
Negri, Sharon
Tarantini, Stefano
Yabluchanskiy, Andriy
Benyo, Zoltan
Csiszar, Anna
Ungvari, Zoltan
The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
title The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
title_full The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
title_fullStr The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
title_full_unstemmed The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
title_short The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
title_sort role of methionine-rich diet in unhealthy cerebrovascular and brain aging: mechanisms and implications for cognitive impairment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650229/
https://www.ncbi.nlm.nih.gov/pubmed/37960316
http://dx.doi.org/10.3390/nu15214662
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