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Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients

Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of...

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Autores principales: Kárász, Nóra, Juhász, Orsolya, Imrei, Marcell, Garami, Miklós
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650320/
https://www.ncbi.nlm.nih.gov/pubmed/37960224
http://dx.doi.org/10.3390/nu15214571
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author Kárász, Nóra
Juhász, Orsolya
Imrei, Marcell
Garami, Miklós
author_facet Kárász, Nóra
Juhász, Orsolya
Imrei, Marcell
Garami, Miklós
author_sort Kárász, Nóra
collection PubMed
description Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of their baseline Vitamin D level and disease outcomes. Methods: We collected data on the initial 25(OH)D concentration in 117 children and examined their RFS and OS using Kaplan–Meier curves. Results: The initial 25(OH)D mean value in the relapsed group was 20.35 ng/mL (SE: 2.05) and in children without relapse it was 26.14 ng/mL (SE: 1.13). Both the relapse-free and overall Kaplan–Meier curves showed a tendency for children with lower serum Vitamin D concentrations to experience cancer recurrence or fatal outcomes sooner than patients with normal serum levels. Conclusions: Our results indicated a possible correlation between higher pretreatment serum Vitamin D concentrations and improved overall and relapse-free survival.
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spelling pubmed-106503202023-10-27 Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients Kárász, Nóra Juhász, Orsolya Imrei, Marcell Garami, Miklós Nutrients Article Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of their baseline Vitamin D level and disease outcomes. Methods: We collected data on the initial 25(OH)D concentration in 117 children and examined their RFS and OS using Kaplan–Meier curves. Results: The initial 25(OH)D mean value in the relapsed group was 20.35 ng/mL (SE: 2.05) and in children without relapse it was 26.14 ng/mL (SE: 1.13). Both the relapse-free and overall Kaplan–Meier curves showed a tendency for children with lower serum Vitamin D concentrations to experience cancer recurrence or fatal outcomes sooner than patients with normal serum levels. Conclusions: Our results indicated a possible correlation between higher pretreatment serum Vitamin D concentrations and improved overall and relapse-free survival. MDPI 2023-10-27 /pmc/articles/PMC10650320/ /pubmed/37960224 http://dx.doi.org/10.3390/nu15214571 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kárász, Nóra
Juhász, Orsolya
Imrei, Marcell
Garami, Miklós
Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients
title Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients
title_full Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients
title_fullStr Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients
title_full_unstemmed Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients
title_short Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients
title_sort long-term prognosis in relation to vitamin d status in pediatric solid tumor patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650320/
https://www.ncbi.nlm.nih.gov/pubmed/37960224
http://dx.doi.org/10.3390/nu15214571
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