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Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients
Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650320/ https://www.ncbi.nlm.nih.gov/pubmed/37960224 http://dx.doi.org/10.3390/nu15214571 |
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author | Kárász, Nóra Juhász, Orsolya Imrei, Marcell Garami, Miklós |
author_facet | Kárász, Nóra Juhász, Orsolya Imrei, Marcell Garami, Miklós |
author_sort | Kárász, Nóra |
collection | PubMed |
description | Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of their baseline Vitamin D level and disease outcomes. Methods: We collected data on the initial 25(OH)D concentration in 117 children and examined their RFS and OS using Kaplan–Meier curves. Results: The initial 25(OH)D mean value in the relapsed group was 20.35 ng/mL (SE: 2.05) and in children without relapse it was 26.14 ng/mL (SE: 1.13). Both the relapse-free and overall Kaplan–Meier curves showed a tendency for children with lower serum Vitamin D concentrations to experience cancer recurrence or fatal outcomes sooner than patients with normal serum levels. Conclusions: Our results indicated a possible correlation between higher pretreatment serum Vitamin D concentrations and improved overall and relapse-free survival. |
format | Online Article Text |
id | pubmed-10650320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106503202023-10-27 Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients Kárász, Nóra Juhász, Orsolya Imrei, Marcell Garami, Miklós Nutrients Article Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of their baseline Vitamin D level and disease outcomes. Methods: We collected data on the initial 25(OH)D concentration in 117 children and examined their RFS and OS using Kaplan–Meier curves. Results: The initial 25(OH)D mean value in the relapsed group was 20.35 ng/mL (SE: 2.05) and in children without relapse it was 26.14 ng/mL (SE: 1.13). Both the relapse-free and overall Kaplan–Meier curves showed a tendency for children with lower serum Vitamin D concentrations to experience cancer recurrence or fatal outcomes sooner than patients with normal serum levels. Conclusions: Our results indicated a possible correlation between higher pretreatment serum Vitamin D concentrations and improved overall and relapse-free survival. MDPI 2023-10-27 /pmc/articles/PMC10650320/ /pubmed/37960224 http://dx.doi.org/10.3390/nu15214571 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kárász, Nóra Juhász, Orsolya Imrei, Marcell Garami, Miklós Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients |
title | Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients |
title_full | Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients |
title_fullStr | Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients |
title_full_unstemmed | Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients |
title_short | Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients |
title_sort | long-term prognosis in relation to vitamin d status in pediatric solid tumor patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650320/ https://www.ncbi.nlm.nih.gov/pubmed/37960224 http://dx.doi.org/10.3390/nu15214571 |
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