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Optimizing contrast protocol for bone‐subtraction CT angiography of intracranial arteries in normal dogs using 160‐slice CT

BACKGROUND: Bone‐subtraction computed tomography angiography (CTA) (BSCTA) is a new technique designed to overcome the limitation of three‐dimensional CTA, where the vessels surrounded by bone and calcification can be obscured. An optimal contrast CT protocol for intracranial artery visualization wi...

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Autores principales: An, Soyon, Hwang, Gunha, Kim, Rakhoon, Cha, Jihye, Lee, Hee Chun, Hwang, Tae‐Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650334/
https://www.ncbi.nlm.nih.gov/pubmed/37766491
http://dx.doi.org/10.1002/vms3.1252
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author An, Soyon
Hwang, Gunha
Kim, Rakhoon
Cha, Jihye
Lee, Hee Chun
Hwang, Tae‐Sung
author_facet An, Soyon
Hwang, Gunha
Kim, Rakhoon
Cha, Jihye
Lee, Hee Chun
Hwang, Tae‐Sung
author_sort An, Soyon
collection PubMed
description BACKGROUND: Bone‐subtraction computed tomography angiography (CTA) (BSCTA) is a new technique designed to overcome the limitation of three‐dimensional CTA, where the vessels surrounded by bone and calcification can be obscured. An optimal contrast CT protocol for intracranial artery visualization with BSCTA has yet to be established in dogs. OBJECTIVES: The purpose of this study was to determine the optimal contrast protocol of CTA for visualizing intracranial artery using an automatic bone‐subtraction technique in dogs. METHODS: Brain CTA was performed four times for each of nine healthy beagle dogs to cover all the contrast protocols: two different contrast iodine concentrations (300 and 370 mgI/mL) and two different contrast media injection rates (2 and 4 mL/s). Bone removal post‐processing was performed automatically by subtracting the non‐enhanced CT data from the contrast CT data using a dedicated workstation. The bone‐subtracted intracranial vessels were analysed for quantitative and qualitative evaluation. RESULTS: Quantitative evaluation showed significantly higher CT attenuation values for the group with a 370 mgI/mL iodine content at a rate of 4 mL/s than the two groups with a 300 mgI/mL iodine content at the rates of 2 and 4 mL/s (p < 0.001). Qualitative assessment revealed significantly higher mean scores for the 370 mgI/mL groups than the 300 mgI/mL groups and significantly higher mean scores for the 4 mL/s groups than the 2 mL/s groups (p < 0.05). CONCLUSIONS: The optimal contrast protocol for BSCTA suggests that high iodine material concentration and high injection rate should be used for strong arterial attenuation and great visualization of the intracranial arterial structure in dogs.
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spelling pubmed-106503342023-09-27 Optimizing contrast protocol for bone‐subtraction CT angiography of intracranial arteries in normal dogs using 160‐slice CT An, Soyon Hwang, Gunha Kim, Rakhoon Cha, Jihye Lee, Hee Chun Hwang, Tae‐Sung Vet Med Sci DOGS BACKGROUND: Bone‐subtraction computed tomography angiography (CTA) (BSCTA) is a new technique designed to overcome the limitation of three‐dimensional CTA, where the vessels surrounded by bone and calcification can be obscured. An optimal contrast CT protocol for intracranial artery visualization with BSCTA has yet to be established in dogs. OBJECTIVES: The purpose of this study was to determine the optimal contrast protocol of CTA for visualizing intracranial artery using an automatic bone‐subtraction technique in dogs. METHODS: Brain CTA was performed four times for each of nine healthy beagle dogs to cover all the contrast protocols: two different contrast iodine concentrations (300 and 370 mgI/mL) and two different contrast media injection rates (2 and 4 mL/s). Bone removal post‐processing was performed automatically by subtracting the non‐enhanced CT data from the contrast CT data using a dedicated workstation. The bone‐subtracted intracranial vessels were analysed for quantitative and qualitative evaluation. RESULTS: Quantitative evaluation showed significantly higher CT attenuation values for the group with a 370 mgI/mL iodine content at a rate of 4 mL/s than the two groups with a 300 mgI/mL iodine content at the rates of 2 and 4 mL/s (p < 0.001). Qualitative assessment revealed significantly higher mean scores for the 370 mgI/mL groups than the 300 mgI/mL groups and significantly higher mean scores for the 4 mL/s groups than the 2 mL/s groups (p < 0.05). CONCLUSIONS: The optimal contrast protocol for BSCTA suggests that high iodine material concentration and high injection rate should be used for strong arterial attenuation and great visualization of the intracranial arterial structure in dogs. John Wiley and Sons Inc. 2023-09-27 /pmc/articles/PMC10650334/ /pubmed/37766491 http://dx.doi.org/10.1002/vms3.1252 Text en © 2023 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle DOGS
An, Soyon
Hwang, Gunha
Kim, Rakhoon
Cha, Jihye
Lee, Hee Chun
Hwang, Tae‐Sung
Optimizing contrast protocol for bone‐subtraction CT angiography of intracranial arteries in normal dogs using 160‐slice CT
title Optimizing contrast protocol for bone‐subtraction CT angiography of intracranial arteries in normal dogs using 160‐slice CT
title_full Optimizing contrast protocol for bone‐subtraction CT angiography of intracranial arteries in normal dogs using 160‐slice CT
title_fullStr Optimizing contrast protocol for bone‐subtraction CT angiography of intracranial arteries in normal dogs using 160‐slice CT
title_full_unstemmed Optimizing contrast protocol for bone‐subtraction CT angiography of intracranial arteries in normal dogs using 160‐slice CT
title_short Optimizing contrast protocol for bone‐subtraction CT angiography of intracranial arteries in normal dogs using 160‐slice CT
title_sort optimizing contrast protocol for bone‐subtraction ct angiography of intracranial arteries in normal dogs using 160‐slice ct
topic DOGS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650334/
https://www.ncbi.nlm.nih.gov/pubmed/37766491
http://dx.doi.org/10.1002/vms3.1252
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