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The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review

Diabetic retinopathy (DR) is renowned as a leading cause of visual loss in working-age populations with its etiopathology influenced by the disturbance of biochemical metabolic pathways and genetic factors, including gene polymorphism. Metabolic pathways considered to have an impact on the developme...

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Autores principales: Sienkiewicz-Szłapka, Edyta, Fiedorowicz, Ewa, Król-Grzymała, Angelika, Kordulewska, Natalia, Rozmus, Dominika, Cieślińska, Anna, Grzybowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650381/
https://www.ncbi.nlm.nih.gov/pubmed/37958858
http://dx.doi.org/10.3390/ijms242115865
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author Sienkiewicz-Szłapka, Edyta
Fiedorowicz, Ewa
Król-Grzymała, Angelika
Kordulewska, Natalia
Rozmus, Dominika
Cieślińska, Anna
Grzybowski, Andrzej
author_facet Sienkiewicz-Szłapka, Edyta
Fiedorowicz, Ewa
Król-Grzymała, Angelika
Kordulewska, Natalia
Rozmus, Dominika
Cieślińska, Anna
Grzybowski, Andrzej
author_sort Sienkiewicz-Szłapka, Edyta
collection PubMed
description Diabetic retinopathy (DR) is renowned as a leading cause of visual loss in working-age populations with its etiopathology influenced by the disturbance of biochemical metabolic pathways and genetic factors, including gene polymorphism. Metabolic pathways considered to have an impact on the development of the disease, as well as genes and polymorphisms that can affect the gene expression, modify the quantity and quality of the encoded product (protein), and significantly alter the metabolic pathway and its control, and thus cause changes in the functioning of metabolic pathways. In this article, the screening of chromosomes and the most important genes involved in the etiology of diabetic retinopathy is presented. The common databases with manuscripts published from January 2000 to June 2023 have been taken into consideration and chosen. This article indicates the role of specific genes in the development of diabetic retinopathy, as well as polymorphic changes within the indicated genes that may have an impact on exacerbating the symptoms of the disease. The collected data will allow for a broader look at the disease and help to select candidate genes that can become markers of the disease.
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spelling pubmed-106503812023-11-01 The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review Sienkiewicz-Szłapka, Edyta Fiedorowicz, Ewa Król-Grzymała, Angelika Kordulewska, Natalia Rozmus, Dominika Cieślińska, Anna Grzybowski, Andrzej Int J Mol Sci Review Diabetic retinopathy (DR) is renowned as a leading cause of visual loss in working-age populations with its etiopathology influenced by the disturbance of biochemical metabolic pathways and genetic factors, including gene polymorphism. Metabolic pathways considered to have an impact on the development of the disease, as well as genes and polymorphisms that can affect the gene expression, modify the quantity and quality of the encoded product (protein), and significantly alter the metabolic pathway and its control, and thus cause changes in the functioning of metabolic pathways. In this article, the screening of chromosomes and the most important genes involved in the etiology of diabetic retinopathy is presented. The common databases with manuscripts published from January 2000 to June 2023 have been taken into consideration and chosen. This article indicates the role of specific genes in the development of diabetic retinopathy, as well as polymorphic changes within the indicated genes that may have an impact on exacerbating the symptoms of the disease. The collected data will allow for a broader look at the disease and help to select candidate genes that can become markers of the disease. MDPI 2023-11-01 /pmc/articles/PMC10650381/ /pubmed/37958858 http://dx.doi.org/10.3390/ijms242115865 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sienkiewicz-Szłapka, Edyta
Fiedorowicz, Ewa
Król-Grzymała, Angelika
Kordulewska, Natalia
Rozmus, Dominika
Cieślińska, Anna
Grzybowski, Andrzej
The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review
title The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review
title_full The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review
title_fullStr The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review
title_full_unstemmed The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review
title_short The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review
title_sort role of genetic polymorphisms in diabetic retinopathy: narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650381/
https://www.ncbi.nlm.nih.gov/pubmed/37958858
http://dx.doi.org/10.3390/ijms242115865
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