Synthesis of Tetracyclic Spirooxindolepyrrolidine-Engrafted Hydantoin Scaffolds: Crystallographic Analysis, Molecular Docking Studies and Evaluation of Their Antimicrobial, Anti-Inflammatory and Analgesic Activities

In a sustained search for novel potential drug candidates with multispectrum therapeutic application, a series of novel spirooxindoles was designed and synthesized via regioselective three-component reaction between isatin derivatives, 2-phenylglycine and diverse arylidene-imidazolidine-2,4-diones (...

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Detalles Bibliográficos
Autores principales: Toumi, Amani, Abdella, Faiza I.A., Boudriga, Sarra, Alanazi, Tahani Y. A., Alshamari, Asma K., Alrashdi, Ahlam Abdulrahman, Dbeibia, Amal, Hamden, Khaled, Daoud, Ismail, Knorr, Michael, Kirchhoff, Jan-Lukas, Strohmann, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650415/
https://www.ncbi.nlm.nih.gov/pubmed/37959862
http://dx.doi.org/10.3390/molecules28217443

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