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Scattering of Attosecond Laser Pulses on a DNA Molecule during Its Nicking and Bending

It is well known that X-ray crystallography is based on X-ray diffraction (XRD) for atoms and molecules. The diffraction pattern arises as a result of scattering of incident radiation, which makes it possible to determine the structure of the scattering substance. With the advent of ultrashort radia...

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Detalles Bibliográficos
Autores principales: Makarov, Dmitry, Kharlamova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650442/
https://www.ncbi.nlm.nih.gov/pubmed/37958558
http://dx.doi.org/10.3390/ijms242115574
Descripción
Sumario:It is well known that X-ray crystallography is based on X-ray diffraction (XRD) for atoms and molecules. The diffraction pattern arises as a result of scattering of incident radiation, which makes it possible to determine the structure of the scattering substance. With the advent of ultrashort radiation sources, the theory and interpretation of X-ray diffraction analysis have remained the same. This work shows that when an attosecond laser pulse is scattered on a DNA molecule, including during its nicking and bending, the pulse duration is an important characteristic of the scattering. In this case, the diffraction pattern changes significantly compared to the previously known scattering theory. The results obtained must be used in XRD theory to study DNA structures, their mutations and damage, since the previously known theory can produce large errors and, therefore, the DNA structure can be “decoding” incorrectly.