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LCK-SafeScreen-Model: An Advanced Ensemble Machine Learning Approach for Estimating the Binding Affinity between Compounds and LCK Target

The lymphocyte-specific protein tyrosine kinase (LCK) is a critical target in leukemia treatment. However, potential off-target interactions involving LCK can lead to unintended consequences. This underscores the importance of accurately predicting the inhibitory reactions of drug molecules with LCK...

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Detalles Bibliográficos
Autores principales:	Cheng, Ying, Ji, Cong, Xu, Jun, Chen, Roufen, Guo, Yu, Bian, Qingyu, Shen, Zheyuan, Zhang, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650606/ https://www.ncbi.nlm.nih.gov/pubmed/37959801 http://dx.doi.org/10.3390/molecules28217382

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